Evidence map›Paper›PMID 34392499›Full record

ReviewBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021

Methods for detection of Helicobacter pylori from stool sample: current options and developments.

Enming Qiu, Zhou Li, Shuai Han

Abstract readReview
In one paragraph

Review in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Clinical validation of a fecal PCR assay forJournal of clinical microbiology · 2026
    Observational
  2. Article
  3. Application value and performance of stool antigen detection in the diagnosis of Helicobacter pylori infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  4. International journal of molecular sciences · 2025
    Review
  5. Article
  6. Development of a colorimetric loop-mediated isothermal amplification assay for Helicobacter pylori detection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  7. Article
  8. Article
  9. Review of Methods for DetectionJGH open : an open access journal of gastroenterology and hepatology · 2025
    Review
  10. Advances in Diagnostic Modalities forLife (Basel, Switzerland) · 2024
    Review
  11. Antimicrobial Susceptibility of CommensalAnimals : an open access journal from MDPI · 2024
    Article
  12. Article
  13. Article
  14. Predictive factors and model validation of post-colon polyp surgeryWorld journal of gastrointestinal surgery · 2024
    Article
  15. Diagnostic Methods for Helicobacter pylori.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Review
  16. Antibiotics (Basel, Switzerland) · 2023
    Review
  17. Diagnosis and Treatment ofDiagnostics (Basel, Switzerland) · 2023
    Review
  18. Antibiotics (Basel, Switzerland) · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Enming QiuGeneral Surgery Center, Department of Gastrointestinal Surgery, Zhujiang Hospital, Southern Medical University, Haizhu District, No.253. Gongye Middle Avenue, Guangzhou, Guangdong, 510280, China.ORCID http://orcid.org/0000-0001-7059-8851
Zhou LiGeneral Surgery Center, Department of Gastrointestinal Surgery, Zhujiang Hospital, Southern Medical University, Haizhu District, No.253. Gongye Middle Avenue, Guangzhou, Guangdong, 510280, China. gzlizhou@smu.edu.cn.ORCID http://orcid.org/0000-0002-4785-261X
Shuai HanGeneral Surgery Center, Department of Gastrointestinal Surgery, Zhujiang Hospital, Southern Medical University, Haizhu District, No.253. Gongye Middle Avenue, Guangzhou, Guangdong, 510280, China. gzhanbo0624@smu.edu.cn.ORCID http://orcid.org/0000-0002-8387-0241

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate detection of Helicobacter pylori infection and determination of antibiotics have significant meaning in clinical practice. The detection methods can be categorized into two types, invasive and non-invasive, but nowadays we use the urease breath test most frequently which is non-invasive. However, many developing countries cannot meet the requirements for having specialized equipment and they lack trained personnel. Also, for the children, it is difficult to make them cooperate for the test. Methods that detect Helicobacter pylori from stool sample can be a promising alternative for detection used in children and mass screening. Stool antigen tests have several advantages such as rapidity, simplicity, and cheapness, though their results may be influenced by the heterogenicity of antigens, the nature of biochemical techniques, and the amount of antigen presented in the stool. PCR-based methods can specifically detect Helicobacter pylori infection and antibiotic resistance by targeting specific gene sequence, but they also are limited by the requirements of facilities and experts, the existence of inhibitory substance, and interference from the dead bacteria. Some novel methods also deserve our attention. Here we summarized the results of researches about methods using stool sample and we hope our work can help clinicians choose the appropriate test in clinical practice.

Indexed as

Bacteriological TechniquesFecesHelicobacter InfectionsHelicobacter pyloriHumansSensitivity and SpecificityDiagnostic methodHelicobacter pyloriPolymerase chain reactionStool antigen testStool sample

Identifiers

PMID34392499
PMCPMC8578210

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.