Evidence map›Paper›PMID 34392134›Full record

ReviewCarbohydrate research2021

Recent advances in enzymatic synthesis of β-glucan and cellulose.

Gregory S Bulmer, Peterson de Andrade, Robert A Field, Jolanda M van Munster

Open access · hybridAbstract readReview
In one paragraph

Review in Carbohydrate research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 43 citations in OpenAlex.

  1. Valorization ofFoods (Basel, Switzerland) · 2026
    Article
  2. Review
  3. The Barley Glycosyltransferase GenePlants (Basel, Switzerland) · 2025
    Article
  4. Immune Camouflage inClinical ophthalmology (Auckland, N.Z.) · 2025
    Article
  5. Article
  6. Review
  7. Transcriptomics and Metabolomics Analysis ofFoods (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Review
  10. Genome Analysis ofMicroorganisms · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gregory S BulmerDepartment of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Peterson de AndradeDepartment of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Robert A FieldDepartment of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Jolanda M van MunsterDepartment of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK; Scotland's Rural College, Edinburgh, UK. Electronic address: Jolanda.van-munster@sruc.ac.uk.
University of Manchester · GBScotland's Rural College · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/J/000C0618Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790
6 · The paper itself

Abstract

Bottom-up synthesis of β-glucans such as callose, fungal β-(1,3)(1,6)-glucan and cellulose, can create the defined compounds that are needed to perform fundamental studies on glucan properties and develop applications. With the importance of β-glucans and cellulose in high-profile fields such as nutrition, renewables-based biotechnology and materials science, the enzymatic synthesis of such relevant carbohydrates and their derivatives has attracted much attention. Here we review recent developments in enzymatic synthesis of β-glucans and cellulose, with a focus on progress made over the last five years. We cover the different types of biocatalysts employed, their incorporation in cascades, the exploitation of enzyme promiscuity and their engineering, and reaction conditions affecting the production as well as in situ self-assembly of (non)functionalised glucans. The recent achievements in the application of glycosyl transferases and β-1,4- and β-1,3-glucan phosphorylases demonstrate the high potential and versatility of these biocatalysts in glucan synthesis in both industrial and academic contexts.

Indexed as

beta-GlucansCelluloseBiocatalysisGlycosyltransferasesbeta-GlucansCelluloseGlycosyltransferasesCelluloseGlucansGlycoside hydrolasesGlycoside phosphorylasesGlycosyltransferasesNanostructures

Identifiers

PMID34392134
PMCPMC8425183
OpenAlexW3185821164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.