Evidence map›Paper›PMID 34392011›Full record

ArticleStem cell research2021

Generation of inducible pluripotent stem cell lines from Alzheimer's disease patients with APOE e3/e3 genotype.

Jihye Lee, Zhong Liu, Ying Gai Tusing, Chao Li, Erik Westin, Wei Li, Rui Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jihye LeeDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Zhong LiuDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ying Gai TusingDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chao LiDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Erik WestinDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Wei LiDepartment of Clinical and Diagnoistic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rui ZhaoDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: ruizhao@uab.edu.

Funding

Explore the APOE e4-mediated p53 activation in Alzheimer's DiseaseR01OD026594 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHAO, RUI · 2019 to 2022
$1.7M
Modeling low-grade gliomas using human pluripotent stem cellsR21NS106430 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HAN, XIAOSI, ZHAO, RUI · 2018 to 2019
$408k
NIH HHS R01 OD026594NINDS NIH HHS R21 NS106430
6 · The paper itself

Abstract

iPSCs were generated from B lymphocytes of two Alzheimer's disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyotypes. These iPSCs can be utilized as an in vitro model to study AD and to evaluate efficacies of new treatments.

Indexed as

Alzheimer DiseaseInduced Pluripotent Stem CellsApolipoproteins ECell DifferentiationGenotypeHomozygoteHumansApolipoproteins E

Identifiers

PMID34392011
PMCPMC8496340

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.