ArticleClinical breast cancer2022
Invasive Breast Cancer Treatment Patterns in Women Age 80 and Over: A Report from the National Cancer Database.
Article in Clinical breast cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Frequency of use and characterization of frailty assessments in observational studies on older women with breast cancer: a systematic review.BMC geriatrics · 2024Pooled it
- The timing of surgery for elderly patients with locally advanced breast cancer.Translational cancer research · 2025Article
- De-Escalation of Treatment in Women Aged ≥80 Years with Breast Cancer: A Retrospective Analysis from Two Breast Centers.Current oncology (Toronto, Ont.) · 2025Article
- The Association Between Psychosocial Factors and Decision Making Regarding Primary Treatment in Older Women With Early-Stage Breast Cancer.Psycho-oncology · 2025Article
- Are there differences in overall survival among older breast cancer patients by race and ethnicity?Surgery · 2025Article
- A Review on Integrating Breast Cancer Clinical Data: A Unified Platform Perspective.Current treatment options in oncology · 2025Review
- Acceptance and results of cryoablation for the treatment of early breast cancer in non-surgical patients.The British journal of radiology · 2024Article
- Does Neoadjuvant Chemotherapy in Clinical T1-T2 N0 Triple-Negative Breast Cancer Increase the Extent of Axillary Surgery?Annals of surgical oncology · 2024Article
- Associations Between Hospital Volume and Overall Survival After Surgery in Older Patients with Breast Cancer.Annals of surgical oncology · 2023Article
- Estimating Breast Cancer Overdiagnosis After Screening Mammography Among Older Women in the United States.Annals of internal medicine · 2023Article
- Quality Indicators Compliance and Survival Outcomes in Breast Cancer according to Age in a Certified Center.Cancers · 2023Article
- Neoadjuvant systemic therapy in geriatric breast cancer patients: a National Cancer Database (NCDB) analysis.Breast cancer research and treatment · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere are no established treatment guidelines for women with breast cancer aged ≥80 despite increasing representation in the US population. Here we identify national treatment patterns and survival outcomes in women with stage I-III invasive breast cancer. PATIENTS AND
methodsWomen age ≥80 diagnosed with stage I-III invasive breast cancer (IBC) were identified from 2005-2014 in the National Cancer Database. χ
resultsA total of 62,575 women with IBC met inclusion criteria, of which the majority received surgery (94%). Receipt of surgery was associated with White race, age <90, lower stage, and fewer comorbidities. OS was higher for those who received surgery compared to those who did not (HR 3.3 [3.18-3.46] P < .001). Molecular subtype analysis demonstrated improved survival with receipt of surgery or radiation for all subtypes, as well as improved survival with chemotherapy for those with triple negative breast cancer.
conclusionThe vast majority of breast cancer patients aged ≥80 in the National Cancer Database with IBC received primary surgical management, which was associated with a significant OS benefit. Due to this finding, surgical resection should be considered for all patients ≥80 who are suitable operative candidates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.