Evidence map›Paper›PMID 34391468›Full record

ArticleMolecular autism2021

Non-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised.

V Courchesne, R Bedford, A Pickles, E Duku, C Kerns, P Mirenda, T Bennett, S Georgiades, I M Smith, W J Ungar and 6 more

Open access · goldAbstract read
In one paragraph

Article in Molecular autism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Diversity of words and words for diversity.Frontiers in psychiatry · 2026
    Article
  3. Article
  4. Categorizing and identifying preferred interests in autistic toddlers.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 3 countries.

V CourchesneDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada. valerie.courchesne@mail.mcgill.ca.ORCID 0000-0001-7768-5448
R BedfordKing's College London, London, UK.
A PicklesKing's College London, London, UK.
E DukuMcMaster University, Hamilton, Canada.
C KernsUniversity of British Columbia, Vancouver, Canada.
P MirendaUniversity of British Columbia, Vancouver, Canada.
T BennettMcMaster University, Hamilton, Canada.
S GeorgiadesMcMaster University, Hamilton, Canada.
I M SmithDalhousie University, IWK Health Centre, Halifax, Canada.
W J UngarProgram of Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
T VaillancourtUniversity of Ottawa, Ottawa, Canada.
A Zaidman-ZaitTel Aviv University, Tel Aviv-Yafo, Israel.
L ZwaigenbaumUniversity of Alberta, Edmonton, Canada.
P SzatmariCentre for Addiction and Mental Health, Hospital for Sick Children, University of Toronto, Toronto, Canada.
M ElsabbaghDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Pathways Team
McMaster University · CAKing's College London · GBMcGill University · CAUniversity of British Columbia · CACentre for Addiction and Mental Health · CADalhousie University · CATel Aviv University · ILUniversity of Alberta · CAUniversity of Ottawa · CAUniversity of Toronto · CA

Funding

CIHR 325198CIHR 358130CIHR FDN 143235CIHR FDN 93621CIHR HDF-70333Department of Health NF-SI-0617-10120Wellcome Trust 204823/Z/16/Z
6 · The paper itself

Abstract

backgroundRestricted and repetitive behavior (RRB) is one of the characteristic features of Autism Spectrum Disorder. This domain of symptoms includes a broad range of behaviors. There is a need to study each behavior individually to better understand the role of each in the development of autistic children. Moreover, there are currently no longitudinal studies investigating change in these behaviors over development.

methodsThe goal of the present study was to explore the association between age and non-verbal IQ (NVIQ) on 15 RRB symptoms included in the Autism Diagnostic Interview-Revised (ADI-R) over time. A total of 205 children with ASD were assessed using the ADI-R at time of diagnosis, at age 6 years, and at age 11 years, and with the Wechsler Intelligence Scales for Children-Fourth Edition (WISC-IV) at age 8 years.

resultsThe proportion of children showing each RRB tended to diminish with increasing age, except for sensitivity to noise and circumscribed interests, where the proportion increased over time. Although there was no significant main effect of NVIQ, there was a significant interaction between age and NVIQ. This was mainly driven by Difficulties with change in routine, for which higher NVIQ was associated with the behavior remaining relatively stable with age, while lower NVIQ was associated with the behavior becoming more prevalent with age. LIMITATIONS: The study focused on the presence/absence of each RRB but did not account for potential changes in frequency or severity of the behaviors over development. Furthermore, some limitations are inherent to the measures used. The ADI-R relies on parent report and hence has some level of subjectivity, while the Wechsler intelligence scales can underestimate the intellectual abilities of some autistic children.

conclusionsThese results confirm that specific RRB are differentially linked to age and NVIQ. Studying RRB individually is a promising approach to better understanding how RRB change over the development of autistic children and are linked to other developmental domains.

Indexed as

Autism Spectrum DisorderAutistic DisorderChildCognitionHumansIntelligence TestsLongitudinal StudiesADI-RAutismBehaviorsIntelligenceInterestLongitudinalRepetitiveRestrictedWechsler

Identifiers

PMID34391468
PMCPMC8364071
OpenAlexW3193784681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.