Evidence map›Paper›PMID 34391420›Full record

ArticleRespiratory research2021

Integration of transbronchial cryobiopsy into multidisciplinary board decision: a single center analysis of one hundred consecutive patients with interstitial lung disease.

Katrin E Hostettler, Michael Tamm, Lukas Bubendorf, Peter Grendelmeier, Kathleen Jahn, Daiana Stolz, Jens Bremerich, Spasenija Savic Prince

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review of procedural and sampling techniques for cryobiopsy in interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrin E HostettlerClinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. Katrin.Hostettler@usb.ch.
Michael TammClinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Lukas BubendorfPathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4054, Basel, Switzerland.
Peter GrendelmeierClinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Kathleen JahnClinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Daiana StolzClinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Jens BremerichDepartment of Radiology, University Hospital Basel, 4031, Basel, Switzerland.
Spasenija Savic PrincePathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4054, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransbronchial cryobiopsy in the evaluation of patients with interstitial lung diseases (ILD) is expected to reduce the need for surgical lung biopsy (SLB).

objectiveTo evaluate the diagnostic value of cryobiopsy in combination with bronchoalveolar lavage (BAL), radiologic and clinical data in patients with ILD.

methodsBetween 08/15 and 01/20 patients with ILD underwent cryobiopsy if they: did not have (i) an usual interstitial pneumonia (UIP)-pattern on CT, (ii) predominant ground-glass opacities suggesting alveolitis, (iii) findings suggestive of sarcoidosis on CT, or if they had (i) a CT showing UIP-pattern, but had findings suggesting alternative diagnosis than idiopathic pulmonary fibrosis (IPF), or (ii) had previous non-diagnostic conventional transbronchial forceps biopsy. Histological findings were integrated into the multidisciplinary team discussion (MDTD) and a diagnostic consensus was sought.

resultsOne hundred patients underwent cryobiopsy. In 88/100 patients, cryobiopsy was representative with diagnostic findings in 45/88 and non-specific histological findings in 43/88 patients. In 25/43 with non-specific findings, a consensus diagnosis was reached after MDTD integrating BAL, radiologic and clinical data; eight of the remaining 18 patients with non-specific findings were referred to SLB. In 12/100 patients cryobiopsy was not representative and three of these patients were also referred to SLB. In 7/11 patients (64%) SLB was diagnostic. Complications of cryobiopsy included pneumothorax (14%) and locally controlled bleeding (24%).

conclusionsThe diagnostic yield of cryobiopsy was 70%:45% of cryobiopsies were diagnostic based on histology alone and an additional 25% provided non-specific, but valuable findings allowing a consensus diagnosis after MDTD. Our data demonstrate that the diagnostic value of cryobiopsy is high if combined with BAL, radiologic and clinical data.

Indexed as

Patient Care TeamAgedBiopsyBronchoalveolar LavageBronchoscopyCryosurgeryFemaleHumansLung Diseases, InterstitialMaleMiddle AgedCryobiopsyInterstitial lung diseaseMultidisciplinary team discussion

Identifiers

PMID34391420
PMCPMC8364042

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.