Evidence map›Paper›PMID 34391165›Full record

Observational studyAmerican journal of otolaryngology

Clinical, virological and immunological evolution of the olfactory and gustatory dysfunction in COVID-19.

Eugenia Maiorano, Anna Calastri, Carlo Robotti, Irene Cassaniti, Fausto Baldanti, Valentina Zuccaro, Edoardo Stellin, Virginia V Ferretti, Catherine Klersy, Marco Benazzo

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of otolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Results from psychophysical tests of smell and taste during the course of SARS-CoV-2 infection: a review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Eugenia MaioranoDepartment of Otorhinolaryngology - Head and Neck Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Anna CalastriDepartment of Otorhinolaryngology - Head and Neck Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Carlo RobottiDepartment of Otorhinolaryngology - Head and Neck Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Electronic address: carlorobotti@gmail.com.
Irene CassanitiMolecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Fausto BaldantiDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Valentina ZuccaroInfectious Diseases Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Edoardo StellinDepartment of Otorhinolaryngology, ASST Valle Olona, Busto Arsizio, Italy.
Virginia V FerrettiClinical Epidemiology and Biometry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Catherine KlersyClinical Epidemiology and Biometry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Marco BenazzoDepartment of Otorhinolaryngology - Head and Neck Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico San Matteo Fondazione · ITOspedale di Circolo di Busto Arsizio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNew-onset olfactory and gustatory dysfunction (OGD) represents a well-acknowledged COVID-19 red flag. Nevertheless, its clinical, virological and serological features are still a matter of debate. MATERIALS AND

methodsFor this cohort study, 170 consecutive subjects with new-onset OGD were consecutively recruited. Otolaryngological examination, OGD subjective grading, nasopharyngeal swabs (NS) for SARS-CoV-2 RNA detection and serum samples (SS) collection for SARS-CoV-2 IgG quantification were conducted at baseline and after one (T1), two (T2) and four weeks (T3).

resultsSARS-CoV-2 infection was confirmed in 79% of patients. Specifically, 43% of positive patients were detected only by SS analysis. The OGD was the only clinical complaint in 10% of cases. Concurrent sinonasal symptoms were reported by 45% of patients. Subjective improvement at T3 was reported by 97% of patients, with 40% recovering completely. Hormonal disorders and RNA detectability in NS were the only variables associated with OGD severity. Recovery rate was higher in case of seasonal influenza vaccination, lower in patients with systemic involvement and severe OGD. Not RNA levels nor IgG titers were correlated with recovery.

conclusionClinical, virological and serological features of COVID-19 related OGD were monitored longitudinally, offering valuable hints for future research on the relationship between host characteristics and chemosensory dysfunctions.

Indexed as

AdultCOVID-19FemaleHumansImmunoglobulin GMaleMiddle AgedOlfaction DisordersSARS-CoV-2Taste DisordersImmunoglobulin GCOVID-19ImmunoglobulinsRNASmellTasteViral load

Identifiers

PMID34391165
PMCPMC8349441
OpenAlexW3188535789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.