Evidence map›Paper›PMID 34391118›Full record

ArticleRespiratory medicine2021

The impact of demographic disparities in the presentation of sarcoidosis: A multicenter prospective study.

Ying Zhou, Alicia K Gerke, Elyse E Lower, Alexander Vizel, Deepak Talwar, Irina Strambu, Joel Francesqui, Jacobo Sellares, Michiru Sawahata, Ogugua Ndili Obi and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Quality of Life in Sarcoidosis.Diagnostics (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Contemporary management of sarcoidosis.Frontiers in medicine · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Big data in sarcoidosis.Current opinion in pulmonary medicine · 2024
    Review
  20. Association of Area Deprivation Index with Adherence to Proposed Regimen in Patients with Sarcoidosis in Detroit, Michigan.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 15 institutions in 10 countries.

Ying ZhouDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China. Electronic address: happyying79550@sina.com.
Alicia K GerkeDepartment of Internal Medicine, Pulmonary and Critical Care, University of Iowa, 200 Hawkins Dr, Iowa City, IA, 52246, USA.
Elyse E LowerInternal Medicine, University of Cincinnati, University of Cincinnati Medical Center, Cincinnati, OH, 45267-0565, USA.
Alexander VizelKazan State Medical University, Department of Phthisiopulmonology. Butlerov Str., 49. Kazan, Tatarsan Republic. 420012, Russian Federation.
Deepak TalwarDepartment of Pulmonary and Sleep Care Medicine, Metro Multispeciality Hospital, Noida, Uttar Pradesh, India.
Irina StrambuPulmonology Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Joel FrancesquiServei de Pneumologia, Respiratory Institute, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
Jacobo SellaresServei de Pneumologia, Respiratory Institute, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
Michiru SawahataDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, 329-0498, Japan.
Ogugua Ndili ObiDivision of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Sonoko NagaiKyoto Central Clinic, Clinical Research Center, Kyoto, Japan.
Kiminobu TanizawaKyoto Central Clinic, Clinical Research Center, Kyoto, Japan; Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Marc A JudsonDepartment of Medicine, Albany Medical College, Albany, NY, USA.
Florence JenyService de Pneumologie, Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Bobigny, France.
Dominique ValeyreService de Pneumologie, Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Bobigny, France.
Marina Dornfeld Cunha CastroDepartment of Medicine, Division of Respiratory Diseases, Interstitial Lung Diseases Center, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Carlos PereiraDepartment of Medicine, Division of Respiratory Diseases, Interstitial Lung Diseases Center, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Meyer BalterDivision of Respirology, Dept of Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Robert P BaughmanInternal Medicine, University of Cincinnati, University of Cincinnati Medical Center, Cincinnati, OH, 45267-0565, USA.
Assistance Publique – Hôpitaux de Paris · FRConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversidade Federal de São Paulo · BRUniversity of Cincinnati · USAlbany Medical Center Hospital · USCarol Davila University of Medicine and Pharmacy · ROEast Carolina University · USJichi Medical University · JPKazan State Medical University · RUKyoto Medical Center · JPKyoto University · JPMidas Multispeciality Hospital · INMount Sinai Hospital · CATongji University · CNUniversity of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
FDA HHS R01 FD005993NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

objectiveTo study how demographic differences impact disease manifestation of sarcoidosis using the WASOG tool in a large multicentric study.

methodsClinical data regarding 1445 patients with sarcoidosis from 14 clinical sites in 10 countries were prospectively reviewed from Feb 1, 2020 to Sep 30, 2020. Organ involvement was evaluated for the whole group and for subgroups differentiated by sex, race, and age.

resultsThe median age of the patients at diagnosis was 46 years old; 60.8% of the patients were female. The most commonly involved organ was lung (96%), followed by skin (24%) and eye (22%). Black patients had more multiple organ involvement than White patients (OR = 3.227, 95% CI: 2.243-4.643) and females had more multiple organ involvement than males (OR = 1.238, 95% CI: 1.083-1.415). Black patients had more frequent involvement of neurologic, skin, eye, extra thoracic lymph node, liver and spleen than White and Asian patients. Women were more likely to have eye (OR = 1.522, 95%CI: 1.259-1.838) or skin involvement (OR = 1.369, 95%CI: 1.152-1.628). Men were more likely to have cardiac involvement (OR = 1.326, 95%CI: 1.096-1.605). A total of 262 (18.1%) patients did not receive systemic treatment for sarcoidosis. Therapy was more common in Black patients than in other races.

conclusionThe initial presentation and treatment of sarcoidosis was related to sex, race, and age. Black and female individuals are found to have multiple organ involvement more frequently. Age at diagnosis<45, Black patients and multiple organ involvement were independent predictors of treatment.

Indexed as

DemographySarcoidosisAdultAge FactorsAmericasAsiaCardiomyopathiesEuropeEye DiseasesFemaleHumansLung DiseasesMaleMiddle AgedMulticenter Studies as TopicProspective StudiesClinical manifestationDemographic disparitiesOrgan involvementSarcoidosis

Identifiers

PMID34391118
PMCPMC9999732
OpenAlexW3192855513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.