ArticleEuropean journal of cancer (Oxford, England : 1990)2021
Late-onset kidney failure in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
Article in European journal of cancer (Oxford, England : 1990), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Global burden and inequality of childhood kidney cancer (1990-2050): a systematic analysis for the global burden of disease study 2021.World journal of urology · 2026Article
- Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study.Cancer medicine · 2026Article
- Long-term adverse effects of modern Wilms tumour therapies: implications for monitoring.Nature reviews. Urology · 2026Review
- Kidney disease and transplantation in childhood cancer survivors.Pediatric nephrology (Berlin, Germany) · 2026Review
- [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Long-Term Kidney Outcomes in Paediatric Osteosarcoma Survivors: A 20-Year Multi-Centre Study.Cancers · 2026Article
- Incidence of and risk factors for chronic kidney disease in childhood cancer survivors.Pediatric nephrology (Berlin, Germany) · 2026Article
- Nephrotoxicity and kidney outcomes in pediatric oncology patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Anthracycline-induced cardiorenal toxicity: from molecular mechanisms to clinical management.Frontiers in cardiovascular medicine · 2026Review
- Updated favourable-histology Wilms tumour risk stratification: rationale for future Children's Oncology Group clinical trials.Nature reviews. Urology · 2025Review
- Trend and Cancer-Specific Prevalence of Kidney Stones Among US Cancer Survivors, 2007-2020.Current oncology (Toronto, Ont.) · 2025Article
- Long-term kidney complications in childhood leukemia survivors: a study from the Childhood and Adolescent Leukemia (LEA) project.Haematologica · 2025Article
- The incidence and outcome of acute kidney injury during pediatric kidney tumor treatment-a national cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Chronic Kidney Disease or Hypertension After Childhood Cancer.JAMA network open · 2025Article
- Long-term kidney function of childhood cancer survivors-who needs to be monitored?Translational pediatrics · 2023Article
- Prediction of kidney failure in long-term survivors of childhood cancer-an opportunity for intervention in follow-up programs.Translational pediatrics · 2023Article
- Acute kidney injury in children with haematological malignancy: a territory-wide study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Children's Oncology Group's 2023 blueprint for research: Renal tumors.Pediatric blood & cancer · 2023Article
- Cumulative burden of late, major surgical intervention in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study (CCSS) cohort.The Lancet. Oncology · 2023Article
- Late Health Outcomes Among Survivors of Wilms Tumor Diagnosed Over Three Decades: A Report From the Childhood Cancer Survivor Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
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Authors and funding
18 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundThe incidence of and risk factors for late-onset kidney failure among survivors over the very long term remains understudied. MATERIALS AND
methodsA total of 25,530 childhood cancer survivors (median follow-up 22.3 years, interquartile range 17.4-28.8) diagnosed between 1970 and 1999, and 5045 siblings from the Childhood Cancer Survivor Study were assessed for self-reported late-onset kidney failure, defined as dialysis, renal transplantation, or death attributable to kidney disease. Piecewise exponential models evaluated associations between risk factors and the rate of late-onset kidney failure.
resultsA total of 206 survivors and 10 siblings developed late-onset kidney failure, a 35-year cumulative incidence of 1.7% (95% confidence interval [CI] = 1.4-1.9) and 0.2% (95% confidence interval [CI] = 0.1-0.4), respectively, corresponding to an adjusted rate ratio (RR) of 4.9 (95% CI = 2.6-9.2). High kidney dose from radiotherapy (≥15Gy; RR = 4.0, 95% CI = 2.1-7.4), exposure to high-dose anthracycline (≥250 mg/m
conclusionsSurvivors of childhood cancer are at increased risk for late-onset kidney failure. Kidney dose from radiotherapy ≥15 Gy, high-dose anthracycline, any ifosfamide, and nephrectomy were associated with increased risk of late-onset kidney failure among survivors. Successful diagnosis and management of modifiable risk factors such as diabetes and hypertension may mitigate the risk for late-onset kidney failure. The association of late-onset kidney failure with anthracycline chemotherapy represents a novel finding that warrants further study.
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