ArticleBioorganic & medicinal chemistry letters2021
Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain.
Liudmila L Mazaleuskaya, Seokwoo Lee, Hu Meng, Jeffrey D Winkler, Garret A FitzGerald
Open access · greenAbstract read
In one paragraphArticle in Bioorganic & medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors at 3 institutions in 1 country.
Liudmila L MazaleuskayaInstitute for Translational Medicine and Therapeutics, the Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mazali@pennmedicine.upenn.edu.
Seokwoo LeeDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mirue7@sas.upenn.edu.
Hu MengInstitute for Translational Medicine and Therapeutics, the Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: menghu@pennmedicine.upenn.edu.
Jeffrey D WinklerDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: winkler@sas.upenn.edu.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, the Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: garret@upenn.edu.
University of Pennsylvania · USPhiladelphia University · USTranslational Therapeutics (United States) · US
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MPilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2016
$18.5MNCATS NIH HHS UL1 TR001878NHLBI NIH HHS U54 HL117798
6 · The paper itselfAbstract
Activated macrophages overexpress the folate receptor β (FR-β) that can be used for targeted delivery of drugs conjugated to folic acid. FR-expressing macrophages contribute to arthritis progression by secreting prostaglandin E
Indexed as
AnimalsDrug Delivery SystemsFolate Receptor 2Gene Expression Regulation, EnzymologicHeterocyclic Compounds, 4 or More RingsHumansInflammationMacrophagesMiceMice, TransgenicPainProstaglandin-E SynthasesFolate Receptor 2Folr2 protein, mouseHeterocyclic Compounds, 4 or More RingsMK-7285Prostaglandin-E SynthasesFolate-drug conjugateFolate receptor betaInflammatory painMacrophagesmPGES-1 inhibitorNSAID
Identifiers
PMID34390827
PMCPMC8484072
OpenAlexW3193968234
What OpenQuestion holds
Textmetadata
LicenceTDM
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