Evidence map›Paper›PMID 34390772›Full record

ArticleNeuroscience letters2021

Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy.

Yanlong Song, Emmanuelle Renoul, Stephanie Acord, Yvette R Johnson, Warren Marks, George Alexandrakis, Christos Papadelis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanlong SongJane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
Emmanuelle RenoulJane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA; Biomedical Engineering, Université de Paris, Paris, France.
Stephanie AcordJane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA.
Yvette R JohnsonNEST Developmental Follow-up Center, Neonatology, Cook Children's Health Care System, Fort Worth, TX, USA; Department of Pediatrics, Texas Christian University and University of North Texas Health Science Center School of Medicine, Fort Worth, TX, USA.
Warren MarksJane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA.
George AlexandrakisDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
Christos PapadelisJane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA; Department of Pediatrics, Texas Christian University and University of North Texas Health Science Center School of Medicine, Fort Worth, TX, USA; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: christos.papadelis@cookchildrens.org.

Funding

Multi-modal neuroimaging in children with congenital hemiplegia to assess functional and anatomical reorganization in relation to hand functionR21HD090549 · NICHD · COOK CHILDREN'S MEDICAL CENTER · PI PAPADELIS, CHRISTOS · 2017 to 2019
$446k
NICHD NIH HHS R21 HD090549
6 · The paper itself

Abstract

Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to ~120 ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after ~100 ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicate abnormal somatosensory functional connectivity in both hemispheres of children with HCP.

Indexed as

Cerebral PalsyChildEvoked Potentials, SomatosensoryFemaleHemiplegiaHumansMagnetoencephalographyMaleSomatosensory CortexCerebral palsyFunctional connectivityMagnetoencephalographyPhase synchronizationPrimary somatosensory cortexSecondary somatosensory cortex

Identifiers

PMID34390772
PMCPMC8882340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.