ArticleThe Journal of allergy and clinical immunology2022
Anaphylaxis knowledge gaps and future research priorities: A consensus report.
Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- A phase II study of Bruton's tyrosine kinase inhibition for the prevention of anaphylaxis.The Journal of clinical investigation · 2023Trial
- Periprocedural allergy evaluation is safe and effective to guide subsequent anesthesia administration.The journal of allergy and clinical immunology. Global · 2026Article
- Global Research Trends in Chronic Care for Comorbid Allergic Diseases: A Web of Science Bibliometric Review (1999-2024).Current allergy and asthma reports · 2025Review
- Lactate in Anaphylaxis: 100 Years On.Sports medicine (Auckland, N.Z.) · 2025Review
- Establishing Priorities for Clinical Education Research: Exploring the Views of UK Professional and Public Stakeholders.The clinical teacher · 2025Article
- Anaphylaxis definition, overview, and clinical support tool: 2024 consensus report-a GAThe Journal of allergy and clinical immunology · 2025Article
- Towards a common approach for managing food allergy and serious allergic reactions (anaphylaxis) at school. GAClinical and translational allergy · 2025Review
- 10 practical priorities to prevent and manage serious allergic reactions: GAClinical and translational allergy · 2024Review
- Epinephrine and anaphylaxis outcomes: Does timing matter?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- How to define severity: A review of allergic reaction severity scoring systems.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Review
- The need to link anaphylaxis signs and symptoms with targeted therapeutic strategies.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Refractory Anaphylaxis: A New Entity for Severe Anaphylaxis.The journal of allergy and clinical immunology. In practice · 2023Review
- Bruton's tyrosine kinase inhibition for the prevention of anaphylaxis: an open-label, phase 2 trial.Research square · 2023Article
- Recent insights into the mechanisms of anaphylaxis.Current opinion in immunology · 2023Review
- Trends and Variation in Pediatric Anaphylaxis Care From 2016 to 2022.The journal of allergy and clinical immunology. In practice · 2023Article
- Active surveillance and clinical analysis of anaphylaxis based on the China Hospital Pharmacovigilance System.Frontiers in pharmacology · 2023Article
- Anaphylaxis: Data Gaps and Research Needs.Immunology and allergy clinics of North America · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
Abstract
backgroundDespite a better understanding of the epidemiology, pathogenesis, and management of patients with anaphylaxis, there remain knowledge gaps. Enumerating and prioritizing these gaps would allow limited scientific resources to be directed more effectively.
objectiveWe sought to systematically describe and appraise anaphylaxis knowledge gaps and future research priorities based on their potential impact and feasibility.
methodsWe convened a 25-member multidisciplinary panel of anaphylaxis experts. Panelists formulated knowledge gaps/research priority statements in an anonymous electronic survey. Four anaphylaxis themed writing groups were formed to refine statements: (1) Population Science, (2) Basic and Translational Sciences, (3) Emergency Department Care/Acute Management, and (4) Long-Term Management Strategies and Prevention. Revised statements were incorporated into an anonymous electronic survey, and panelists were asked to rate the impact and feasibility of addressing statements on a continuous 0 to 100 scale.
resultsThe panel generated 98 statements across the 4 anaphylaxis themes: Population Science (29), Basic and Translational Sciences (27), Emergency Department Care/Acute Management (24), and Long-Term Management Strategies and Prevention (18). Median scores for impact and feasibility ranged from 50.0 to 95.0 and from 40.0 to 90.0, respectively. Key statements based on median rating for impact/feasibility included the need to refine anaphylaxis diagnostic criteria, identify reliable diagnostic, predictive, and prognostic anaphylaxis bioassays, develop clinical prediction models to standardize postanaphylaxis observation periods and hospitalization criteria, and determine immunotherapy best practices.
conclusionsWe identified and systematically appraised anaphylaxis knowledge gaps and future research priorities. This study reinforces the need to harmonize scientific pursuits to optimize the outcomes of patients with and at risk of anaphylaxis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.