Observational studyThe European journal of neuroscience2021
Alcohol use and brain morphology in adolescence: A longitudinal study in three different cohorts.
Observational study in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- The effects of adolescent social isolation and group housing on adolescent binge drinking in mice.PloS one · 2026Article
- Self-Control, Intoxication and Violence: A Cross-National Comparison of English and Swedish Adolescents.International criminology · 2026Article
- Socioemotional and Executive Control Mismatch in Adolescence and Risks for Initiating Drinking.JAMA network open · 2025Article
- Disentangling the effects of self-control and the use of tobacco and cannabis on violence perpetration from childhood to early adulthood.European child & adolescent psychiatry · 2025Article
- The impact of the CACNB2 Rs11013860 polymorphism on grey matter volume and brain function in bipolar disorder.BMC psychiatry · 2025Article
- Differential effects of moderate chronic ethanol consumption on neurobehavior, white matter glial protein expression, and mTOR pathway signaling with adolescent brain maturation.The American journal of drug and alcohol abuse · 2024Article
- Adolescent substance use initiation and long-term neurobiological outcomes: insights, challenges and opportunities.Molecular psychiatry · 2024Review
- Use of Tobacco Products and Suicide Attempts Among Elementary School-Aged Children.JAMA network open · 2024Article
- Chronic Pain and Cannabis Use Frequency, Intensity, and Severity in Young Adults.Substance use & misuse · 2024Article
- Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development.Frontiers in molecular neuroscience · 2024Article
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
- Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples.Developmental cognitive neuroscience · 2023Article
- Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies.Addiction biology · 2023Review
- Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.Molecular psychiatry · 2023Review
- Adolescent binge ethanol impacts H3K36me3 regulation of synaptic genes.Frontiers in molecular neuroscience · 2023Article
- Adolescent social housing protects against adult emotional and cognitive deficits and alters the PFC and NAc transcriptome in male and female C57BL/6J mice.Frontiers in neuroscience · 2023Article
- Alcohol and cannabis co-use and longitudinal gray matter volumetric changes in early and late adolescence.Addiction biology · 2022Article
- Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice.Behavioural brain research · 2022Article
- Areas of Convergence and Divergence in Adolescent Social Isolation and Binge Drinking: A Review.Frontiers in behavioral neuroscience · 2022Review
- Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol consumption is commonly initiated during adolescence, but the effects on human brain development remain unknown. In this multisite study, we investigated the longitudinal associations of adolescent alcohol use and brain morphology. Three longitudinal cohorts in the Netherlands (BrainScale n = 200, BrainTime n = 239 and a subsample of the Generation R study n = 318) of typically developing participants aged between 8 and 29 years were included. Adolescent alcohol use was self-reported. Longitudinal neuroimaging data were collected for at least two time points. Processing pipelines and statistical analyses were harmonized across cohorts. Main outcomes were global and regional brain volumes, which were a priori selected. Linear mixed effect models were used to test main effects of alcohol use and interaction effects of alcohol use with age in each cohort separately. Alcohol use was associated with adolescent's brain morphology showing accelerated decrease in grey matter volumes, in particular in the frontal and cingulate cortex volumes, and decelerated increase in white matter volumes. No dose-response association was observed. The findings were most prominent and consistent in the older cohorts (BrainScale and BrainTime). In summary, this longitudinal study demonstrated differences in neurodevelopmental trajectories of grey and white matter volume in adolescents who consume alcohol compared with non-users. These findings highlight the importance to further understand underlying neurobiological mechanisms when adolescents initiate alcohol consumption. Therefore, further studies need to determine to what extent this reflects the causal nature of this association, as this longitudinal observational study does not allow for causal inference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.