Evidence map›Paper›PMID 34390461›Full record

ArticleJournal of endocrinological investigation2022

Sclerostin and bone turnover markers response to cycling and running at the same moderate-to-vigorous exercise intensity in healthy men.

N Dror, J Carbone, F Haddad, B Falk, P Klentrou, S Radom-Aizik

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Osteocalcin and GPR158: linking bone and brain function.Frontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Effects of Six-Week Resistance Training with or without Vibration on Metabolic Markers of Bone Metabolism.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

N DrorPediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, 101 Academy, Suite 150, Irvine, CA, 92617, USA.ORCID http://orcid.org/0000-0003-0813-7426
J CarbonePediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, 101 Academy, Suite 150, Irvine, CA, 92617, USA.
F HaddadPediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, 101 Academy, Suite 150, Irvine, CA, 92617, USA.
B FalkDepartment of Kinesiology, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON, Canada.
P KlentrouDepartment of Kinesiology, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON, Canada.
S Radom-AizikPediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, 101 Academy, Suite 150, Irvine, CA, 92617, USA. saizik@uci.edu.
University of California, Irvine · USBrock University · CA

Funding

Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child HealthU01TR002004 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, RADOM-AIZIK, SHLOMIT · 2018 to 2022
$6.5M
NIH HHS U01-TR002004
6 · The paper itself

Abstract

backgroundRecreational cycling is a popular activity which stimulates and improves cardiovascular fitness. The corresponding benefits for bone are unclear. PURPOSE: This study examined the effect of running (high-impact) vs. cycling (low-impact), at the same moderate-to-vigorous exercise intensity, on markers of bone formation (N-terminal propeptide of type I collagen, PINP) and bone resorption (C-telopeptide of type I collagen, CTX-1), a non-collagenous bone remodeling marker (osteocalcin), as well as bone-modulating factors, including parathyroid hormone (PTH), irisin (myokine) and sclerostin (osteokine).

methodsThirteen healthy men (23.7 ± 1.0 y) performed two progressive exercise tests to exhaustion (peak VO

resultsPTH transiently increased (CE, 51.7%; TM, 50.6%) immediately after exercise in both exercise modes. Sclerostin levels increased following running only (27.7%). Irisin increased following both running and cycling. In both exercise modes, CTX-1 decreased immediately after exercise, with no significant change in PINP and osteocalcin.

conclusionAt the same moderate-to-vigorous exercise intensity, running appears to result in a greater transient sclerostin response compared with cycling, while the responses of bone markers, PTH and irisin are similar. The longer-term implications of this differential bone response need to be further examined.

Indexed as

Adaptor Proteins, Signal TransducingBiomarkersBone and BonesBone RemodelingBone ResorptionCollagen Type ICorrelation of DataExercise TestFibronectinsHealthy VolunteersHumansMaleOsteocalcinOsteogenesisParathyroid HormonePeptide FragmentsAdaptor Proteins, Signal TransducingBGLAP protein, humanBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptideFibronectinsFNDC5 protein, humanOsteocalcinParathyroid HormonePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideSOST protein, humanBoneExerciseIrisinPTHSclerostin

Identifiers

PMID34390461
OpenAlexW3189950168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.