ArticleBrain structure & function2021
Dissecting whole-brain conduction delays through MRI microstructural measures.
Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Axon Diameter Mapping in the Living Human Brain with Ultra-High-Gradient Diffusion MRI at 500 mT/m Gradient Strength.Human brain mapping · 2026Article
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fiber calibre, and vascularization.GeroScience · 2026Article
- The role of white matter myelin in structural-functional network coupling.Communications biology · 2026Article
- 40 Years of diffusion MRI in the brain: From history to emerging frontiers.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Mapping Brain Lesions to Conduction Delays: The Next Step for Personalized Brain Models in Multiple Sclerosis.Human brain mapping · 2025Article
- WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis.Scientific data · 2025Article
- Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Single-subject electroencephalography measurement of interhemispheric transfer time for the in-vivo estimation of axonal morphology.Human brain mapping · 2023Article
- Multiscale effects of excitatory-inhibitory homeostasis in lesioned cortical networks: A computational study.PLoS computational biology · 2023Article
- Novel insights into axon diameter and myelin content in late childhood and adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.NeuroImage · 2022Review
- Multi-Contrast Magnetic Resonance Imaging of Visual White Matter Pathways in Patients With Glaucoma.Investigative ophthalmology & visual science · 2022Article
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5 authors.
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Abstract
Network models based on structural connectivity have been increasingly used as the blueprint for large-scale simulations of the human brain. As the nodes of this network are distributed through the cortex and interconnected by white matter pathways with different characteristics, modeling the associated conduction delays becomes important. The goal of this study is to estimate and characterize these delays directly from the brain structure. To achieve this, we leveraged microstructural measures from a combination of advanced magnetic resonance imaging acquisitions and computed the main determinants of conduction velocity, namely axonal diameter and myelin content. Using the model proposed by Rushton, we used these measures to calculate the conduction velocity and estimated the associated delays using tractography. We observed that both the axonal diameter and conduction velocity distributions presented a rather constant trend across different connection lengths, with resulting delays that scale linearly with the connection length. Relying on insights from graph theory and Kuramoto simulations, our results support the approximation of constant conduction velocity but also show path- and region-specific differences.
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