ArticleThe journal of pathology. Clinical research2021
Malignant transformation of salivary gland pleomorphic adenoma: proof of principle.
Article in The journal of pathology. Clinical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review.Acta cirurgica brasileira · 2024Pooled it
- Recurrence or persistence? Rethinking the natural history of parotid pleomorphic adenoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Patient-derived 3D organotypic co-cultures as a long-term ex vivo model for pleomorphic adenoma of the parotid gland.Scientific reports · 2026Article
- The paradox of benign histology and malignant behavior: lymphatic metastasis in pleomorphic adenoma-a case report.Journal of medical case reports · 2026Article
- Pleomorphic adenoma: does the immunohistochemical profile direct the clinical profile: retrospective study and review of literature.BMC cancer · 2026Review
- Article
- Large Pleomorphic Adenoma of The Upper Lip in a Middle-Aged Woman With Facial Deformity, Tooth Displacement, and Bone Loss: Uncommon Clinical Presentation of a Benign Tumor.Case reports in dentistry · 2026Article
- Habitat Radiomics Analysis Based on Non-contrast CT in Differentiation of Parotid Pleomorphic Adenoma and AdenolymphomaCurrent medical imaging · 2026Article
- Benign Epithelial Salivary Neoplasms: Single-Centered Histopathologic and Clinicodemographic Romanian Retrospective Study.Clinics and practice · 2025Article
- Role of fine needle aspiration biopsy in the diagnosis of pleomorphic adenoma.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Article
- Article
- Pleomorphic adenoma with extensive oncocytic change in the parotid gland: a case report and review.Gland surgery · 2025Article
- Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Mucoepidermoid carcinoma-a rare salivary gland-type tumor of the breast: are we dealing with primary or secondary?-a case report and literature review.Gland surgery · 2024Article
- Review
- Frequent apocrine changes in pleomorphic adenoma with malignant transformation: a possible pre-malignant step in ductal carcinoma ex pleomorphic adenoma.Journal of pathology and translational medicine · 2023Article
- Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report.Cureus · 2023Article
- Identification of differentially expressed microRNAs as potential biomarkers for carcinoma ex pleomorphic adenoma.Scientific reports · 2022Article
- Surgical Treatment of a Giant Pleomorphic Adenoma of the Submandibular Gland: A Case Report.Frontiers in surgery · 2021Article
- Interpretable Deep Learning Radiomics for Differentiating Pleomorphic Adenoma and Warthin Tumor.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supposed risk of malignant transformation of salivary gland pleomorphic adenoma (SGPA) is an important reason for aggressive retreatment in recurrent pleomorphic adenoma (RPA). However, although the diagnostic category 'carcinoma ex-pleomorphic adenoma' suggests that malignant transformation of a pleomorphic adenoma is a regular event, this has to date not been shown to occur in sequential lesions of one patient. Here, we show the molecular events in transformation to malignancy of a pleomorphic adenoma of the parotid gland. Detailed molecular analysis revealed an LIFR/PLAG1 translocation characteristic for pleomorphic adenoma and, next to this, a PIK3R1 frameshift mutation and several allelic imbalances. In subsequent malignant recurrences, the same LIFR/PLAG1 translocation, PIK3R1 frameshift mutation, and allelic imbalances were present in addition to TP53 mutations. Thus, this case not only shows malignant transformation of SGPA, but also demonstrates that molecular analysis can be of help in recognising malignancy in the rare instance of RPA.
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