Evidence map›Paper›PMID 34390065›Full record

ArticleJournal of occupational health2021

Assessment of dermal exposure to N,N-dimethylacetamide in spray workers by combining personal exposure monitoring, biological monitoring, and glove permeation monitoring: A pilot study.

Shinobu Yamamoto, Akito Takeuchi, Yuichiro Yoshida, Osamu Nishinoiri, Masayoshi Ichiba, Hiroyuki Miyauchi

Abstract readCase Reports
In one paragraph

Article in Journal of occupational health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shinobu YamamotoDepartment of Environmental Measurement and Control, University of Occupational and Environmental Health, Japan.ORCID https://orcid.org/0000-0002-0523-1794
Akito TakeuchiOsaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Japan.ORCID https://orcid.org/0000-0003-1782-6565
Yuichiro YoshidaNishinihon Occupational Health Service Center, Japan.
Osamu NishinoiriKanto Regional Safety and Health Service Center, Japan Industrial Safety and Health Association, Japan.
Masayoshi IchibaDepartment of Social Medicine, Saga University, Japan.
Hiroyuki MiyauchiDepartment of Environmental Measurement and Control, University of Occupational and Environmental Health, Japan.

Funding

Japan Society for the Promotion of Science JP17K18303
6 · The paper itself

Abstract

objectivesWe assessed dermal exposure to N,N-dimethylacetamide (DMAC) in a spray worker by utilizing a combination of personal exposure monitoring, biological monitoring, and glove permeation monitoring. We also determined the protective effects of chemical protective gloves (CPGs).

methodsSurveys with and without CPG usage were performed on different days. In the survey with CPG usage, the worker had worn leather gloves over the CPG. Personal exposure monitoring and glove permeation monitoring were performed using 3M Organic Vapor Monitor 3500 and PERMEA-TEC Pads respectively. Urinary concentration of DMAC and its metabolites (N-methylacetamide [NMAC], N-hydroxymethyl-N-methylacetamide [DMAC-OH], S-(acetamidomethyl) mercapturic acid [AMMA]) were measured in the before-shift and end-of-shift samples collected from the worker.

resultsPersonal exposure DMAC concentration in the survey with CPG usage (0.32 ppm) was twice that in the survey without CPG usage (0.15 ppm). However, urinary concentrations of DMAC-OH and AMMA in the end-of-shift samples in the survey with CPG usage (DMAC-OH, 0.74 mg/g creatinine; AMMA, 0.10 mg/g creatinine) were lower than those in the survey without CPG usage (DMAC-OH, 1.27 mg/g creatinine; AMMA, 0.24 mg/g creatinine). Urinary concentrations of DMAC and NMAC were below the limit of detection in all samples. DMAC concentrations in PERMEA-TEC Pads that were used in the surveys with and without CPG usage were in the range of 0.3-2.1 µg/sample and 16.4-1985.2 µg/sample respectively.

conclusionsThe combination of CPG usage and leather gloves was effective in preventing dermal exposure to DMAC.

Indexed as

Protective ClothingAcetamidesAir Pollutants, OccupationalBiological MonitoringHumansOccupational ExposurePilot ProjectsAcetamidesAir Pollutants, OccupationaldimethylacetamideN-methylacetamidedermal exposureexposure evaluationmonitoringN,N-dimethylacetamide (DMAC)

Identifiers

PMID34390065
PMCPMC8361812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.