Evidence map›Paper›PMID 34390050›Full record

ArticleInternational journal of methods in psychiatric research2021

Cardiovascular reactivity as a measure of irritability in a transdiagnostic sample of youth: Preliminary associations.

Reut Naim, Matthew S Goodwin, Kelly Dombek, Olga Revzina, Courtney Agorsor, Kyunghun Lee, Christian Zapp, Gabrielle F Freitag, Simone P Haller, Elise Cardinale and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of methods in psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
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  8. Article
  9. Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024
    Review
  10. Article
  11. Article
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  13. Article
  14. Review
  15. Article
  16. Frustration, Cognition, and Psychophysiology in Dysregulated Children: A Research Domain Criteria Approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Reut NaimEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-0424-5094
Matthew S GoodwinDepartment of Health Sciences, Khoury College of Computer Sciences, Northeastern University, Boston, Massachusetts, USA.
Kelly DombekEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Olga RevzinaEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Courtney AgorsorEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Kyunghun LeeEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Christian ZappEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Gabrielle F FreitagEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Simone P HallerEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Elise CardinaleEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
David JangrawEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Melissa A BrotmanEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USNortheastern University · US

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
Intramural NIH HHS ZIA MH002778Intramural NIH HHS ZIA MH002786
6 · The paper itself

Abstract

objectivesIrritability is a transdiagnostic symptom in developmental psychopathology, conceptualized as a low threshold for frustration and increased proneness to anger. While central to emotion regulation, there is a vital need for empirical studies to explore the relationship between irritability and underlying physiological mechanisms of cardiovascular arousal.

methodsWe examined the relationship between irritability and cardiovascular arousal (i.e., heart rate [HR] and heart rate variability [HRV]) in a transdiagnostic sample of 51 youth (M = 12.63 years, SD = 2.25; 62.7% male). Data was collected using the Empatica E4 during a laboratory stop-signal task. In addition, the impact of motion activity, age, medication, and sleep on cardiovascular responses was explored.

resultsMain findings showed that irritability was associated with increased HR and decreased HRV during task performance.

conclusionsFindings support the role of peripheral physiological dysregulation in youth with emotion regulation problems and suggest the potential use of available wearable consumer electronics as an objective measure of irritability and physiological arousal in a transdiagnostic sample of youth.

Indexed as

FrustrationIrritable MoodAdolescentFemaleHumansMalearousalchild/adolescenceheart rateheart rate variabilityirritabilitysleep

Identifiers

PMID34390050
PMCPMC8633925
OpenAlexW3191622209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.