ArticleJournal of child psychology and psychiatry, and allied disciplines2022
Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Associations between lifestyle, genetic liability for severe mental illness and risk of incident somatic illnesses.Translational psychiatry · 2026Article
- Can We Improve the Prediction of Early Onset Mania and Hypomania in the Community?Bipolar disorders · 2026Article
- Polygenic scores for executive functioning as predictors of performance improvements after repeated testing in major psychiatric disorders.Scientific reports · 2026Article
- Joint developmental trajectories of anxious/depressive symptoms and aggressive behavior in Chinese adolescents: The roles of contextual, personality, and cognitive factors.Scientific reports · 2026Article
- Specificity of Polygenic Scores for Psychiatric Disorders Beyond Transdiagnostic Genetic Risk.JAMA network open · 2026Article
- Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.Biological psychiatry · 2026Article
- Multiple polygenic score approach in colorectal cancer risk prediction.Scientific reports · 2025Article
- Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood.Nature communications · 2025Article
- Understanding the needs of postpartum emerging adults with substance use disorders to improve recovery supports.Frontiers in public health · 2025Article
- Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.Nature communications · 2024Article
- Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample.medRxiv : the preprint server for health sciences · 2024Article
- Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium.Developmental psychobiology · 2024Article
- Noradrenergic gene variation shaping vulnerability and resilience by affecting mental health-related characteristics: A systematic review.Neuroscience applied · 2024Article
- The polygenic and reactive nature of observed parenting.Genes, brain, and behavior · 2023Article
- Joint polygenic and environmental risks for childhood attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom dimensions.JCPP advances · 2023Article
- Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.Nature neuroscience · 2023Article
- Childhood trajectories of internalising and externalising problems associated with a polygenic risk score for neuroticism in a UK birth cohort study.JCPP advances · 2023Article
- The DREAM BIG project as a model for harmonizing early measures of parental care and parent-child interactions across epidemiological cohorts.Frontiers in child and adolescent psychiatry · 2023Article
- Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals.Clocks & sleep · 2022Article
- Research Review: A guide to computing and implementing polygenic scores in developmental research.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
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Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
Abstract
backgroundPolygenic risk scores (PRSs) operationalize genetic propensity toward a particular mental disorder and hold promise as early predictors of psychopathology, but before a PRS can be used clinically, explanatory power must be increased and the specificity for a psychiatric domain established. To enable early detection, it is crucial to study these psychometric properties in childhood. We examined whether PRSs associate more with general or with specific psychopathology in school-aged children. Additionally, we tested whether psychiatric PRSs can be combined into a multi-PRS score for improved performance.
methodsWe computed 16 PRSs based on GWASs of psychiatric phenotypes, but also neuroticism and cognitive ability, in mostly adult populations. Study participants were 9,247 school-aged children from three population-based cohorts of the DREAM-BIG consortium: ALSPAC (UK), The Generation R Study (Netherlands), and MAVAN (Canada). We associated each PRS with general and specific psychopathology factors, derived from a bifactor model based on self-report and parental, teacher, and observer reports. After fitting each PRS in separate models, we also tested a multi-PRS model, in which all PRSs are entered simultaneously as predictors of the general psychopathology factor.
resultsSeven PRSs were associated with the general psychopathology factor after multiple testing adjustment, two with specific externalizing and five with specific internalizing psychopathology. PRSs predicted general psychopathology independently of each other, with the exception of depression and depressive symptom PRSs. Most PRSs associated with a specific psychopathology domain, were also associated with general child psychopathology.
conclusionsThe results suggest that PRSs based on current GWASs of psychiatric phenotypes tend to be associated with general psychopathology, or both general and specific psychiatric domains, but not with one specific psychopathology domain only. Furthermore, PRSs can be combined to improve predictive ability. PRS users should therefore be conscious of nonspecificity and consider using multiple PRSs simultaneously, when predicting psychiatric disorders.
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