ArticleScientific reports2021
Citral modulates virulence factors in methicillin-resistant Staphylococcus aureus.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
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- Leveraging the antibacterial and antibiofilm activities of Cymbopogon flexuosus essential oil against multidrug-resistant bacteria recovered from avian colibacillosis and bovine mastitis: in vitro and molecular docking insights.Veterinary research communications · 2026Article
- Impact of gamma irradiation on lemongrass (Cymbopogon citratus): phytochemical content, antioxidant and antibacterial activity.BMC biotechnology · 2026Article
- Counteracting methicillin resistant Staphylococcus aureus through novel Citral-Azithromycin combination.Scientific reports · 2025Article
- A Paradigm Shift in SSTI Management: The Multifunctional Role of Extracellular Vesicles.International journal of molecular sciences · 2025Review
- DisarmingPathogens (Basel, Switzerland) · 2025Review
- Natural compounds in the fight againstFrontiers in pharmacology · 2024Review
- In Vitro and In Vivo Activity of Citral in Combination with Amphotericin B, Anidulafungin and Fluconazole againstJournal of fungi (Basel, Switzerland) · 2023Article
- β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo.Scientific reports · 2022Article
- Chemical Composition, Antioxidant, Antibacterial, and Antibiofilm Activities ofMolecules (Basel, Switzerland) · 2022Article
- Uncovering the Industrial Potentials of Lemongrass Essential Oil as a Food Preservative: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Composition, Anti-MRSA Activity and Toxicity of Essential Oils fromMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for high morbidity and mortality rates. Citral has been studied in the pharmaceutical industry and has shown antimicrobial activity. This study aimed to analyze the antimicrobial activity of citral in inhibiting biofilm formation and modulating virulence genes, with the ultimate goal of finding a strategy for treating infections caused by MRSA strains. Citral showed antimicrobial activity against MRSA isolates with minimum inhibitory concentration (MIC) values between 5 mg/mL (0.5%) and 40 mg/mL (4%), and minimum bactericidal concentration (MBC) values between 10 mg/mL (1%) and 40 mg/mL (4%). The sub-inhibitory dose was 2.5 mg/mL (0.25%). Citral, in an antibiogram, modulated synergistically, antagonistically, or indifferent to the different antibiotics tested. Prior to evaluating the antibiofilm effects of citral, we classified the bacteria according to their biofilm production capacity. Citral showed greater efficacy in the initial stage, and there was a significant reduction in biofilm formation compared to the mature biofilm. qPCR was used to assess the modulation of virulence factor genes, and icaA underexpression was observed in isolates 20 and 48. For icaD, seg, and sei, an increase was observed in the expression of ATCC 33,591. No significant differences were found for eta and etb. Citral could be used as a supplement to conventional antibiotics for MRSA infections.
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