Evidence map›Paper›PMID 34389748›Full record

ArticleScientific reports2021

Patient-specific computational simulation of coronary artery bifurcation stenting.

Shijia Zhao, Wei Wu, Saurabhi Samant, Behram Khan, Ghassan S Kassab, Yusuke Watanabe, Yoshinobu Murasato, Mohammadali Sharzehee, Janaki Makadia, Daniel Zolty and 13 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  8. Review
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  11. Advancements in Coronary Bifurcation Stenting Techniques: Insights From Computational and Bench Testing Studies.International journal for numerical methods in biomedical engineering · 2025
    Review
  12. Artificial Intelligence in Coronary Artery Interventions: Preprocedural Planning and Procedural Assistance.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Numerical modeling and analysis of cardiac stent using blood hammer principle.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
    Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 15 institutions in 7 countries.

Shijia Zhao *Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Wei Wu *Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Saurabhi SamantCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Behram KhanCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Ghassan S KassabCalifornia Medical Innovation Institute, San Diego, CA, USA.
Yusuke WatanabeDepartment of Cardiology, Teikyo University Hospital, Tokyo, Japan.
Yoshinobu MurasatoDepartment of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Mohammadali SharzeheeCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Janaki MakadiaCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Daniel ZoltyCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Anastasios PanagopoulosCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Francesco BurzottaDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco MigliavaccaLaboratory of Biological Structure Mechanics (LaBS), Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Milan, Italy.
Thomas W JohnsonDepartment of Cardiology, Bristol Heart Institute, University Hospitals Bristol NHSFT and University of Bristol, Bristol, UK.
Thierry LefevreRamsay Générale de Santé - Institut cardiovasculaire Paris Sud, Hopital Privé Jacques Cartier, Massy, France.
Jens Flensted LassenDepartment of Cardiology B, Odense Universitets Hospital and University of Southern Denmark, Odense C, Denmark.
Emmanouil S BrilakisMinneapolis Heart Institute, Minneapolis, MN, USA.
Deepak L BhattBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
George DangasThe Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Hospital, Icahn School of Medicine, New York City, NY, USA.
Claudio ChiastraPoliTo(BIO)Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
Goran StankovicDepartment of Cardiology, Clinical Center of Serbia, Belgrade, Serbia.
Yves LouvardInstitut Cardiovasculaire Paris Sud, Massy, France.
Yiannis S ChatzizisisCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA. ychatzizisis@icloud.com.
University of Nebraska Medical Center · USBrigham and Women's Hospital · USCalifornia Medical Innovations Institute · USCentar za Promociju Nauke · RSHôpital Privé Jacques Cartier · FRInstitut Cardiovasculaire Paris Sud · FRMinneapolis Heart Institute Foundation · USMount Sinai Hospital · USNational Kyushu Medical Center · JPOdense University Hospital · DKPolitecnico di Milano · ITPolytechnic University of Turin · ITTeikyo University Hospital · JPUniversità Cattolica del Sacro Cuore · ITUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

Patient-Specific Simulations to Guide Coronary Bifurcation StentingR01HL144690 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHATZIZISIS, IOANNIS S · 2019 to 2023
$3.9M
NHLBI NIH HHS R01 HL144690
6 · The paper itself

Abstract

Patient-specific and lesion-specific computational simulation of bifurcation stenting is an attractive approach to achieve individualized pre-procedural planning that could improve outcomes. The objectives of this work were to describe and validate a novel platform for fully computational patient-specific coronary bifurcation stenting. Our computational stent simulation platform was trained using n = 4 patient-specific bench bifurcation models (n = 17 simulations), and n = 5 clinical bifurcation cases (training group, n = 23 simulations). The platform was blindly tested in n = 5 clinical bifurcation cases (testing group, n = 29 simulations). A variety of stent platforms and stent techniques with 1- or 2-stents was used. Post-stenting imaging with micro-computed tomography (μCT) for bench group and optical coherence tomography (OCT) for clinical groups were used as reference for the training and testing of computational coronary bifurcation stenting. There was a very high agreement for mean lumen diameter (MLD) between stent simulations and post-stenting μCT in bench cases yielding an overall bias of 0.03 (- 0.28 to 0.34) mm. Similarly, there was a high agreement for MLD between stent simulation and OCT in clinical training group [bias 0.08 (- 0.24 to 0.41) mm], and clinical testing group [bias 0.08 (- 0.29 to 0.46) mm]. Quantitatively and qualitatively stent size and shape in computational stenting was in high agreement with clinical cases, yielding an overall bias of < 0.15 mm. Patient-specific computational stenting of coronary bifurcations is a feasible and accurate approach. Future clinical studies are warranted to investigate the ability of computational stenting simulations to guide decision-making in the cardiac catheterization laboratory and improve clinical outcomes.

Indexed as

Blood Vessel ProsthesisComputer SimulationStentsBlood Vessel Prosthesis ImplantationCoronary Artery DiseaseCoronary VesselsHumansPreoperative CareProsthesis DesignX-Ray Microtomography

Identifiers

PMID34389748
PMCPMC8363606
OpenAlexW3191671143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.