Evidence map›Paper›PMID 34389690›Full record

ArticleMolecular cancer research : MCR2021

SHP2 Potentiates the Oncogenic Activity of β-Catenin to Promote Triple-Negative Breast Cancer.

Elisha Martin, Yehenew M Agazie

Open access · greenAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Complex Roles ofAnnual review of cancer biology · 2024
    Article
  4. Tyrosine phosphataseFrontiers in immunology · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. A comprehensive review of SHP2 and its role in cancer.Cellular oncology (Dordrecht, Netherlands) · 2022
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elisha MartinDepartment of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia.
Yehenew M AgazieDepartment of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia. yagazie@hsc.wvu.edu.
West Virginia University · US

Funding

Targeting SHP2 as a precision medicine for the treatment of HER2-positive breast cancerR01CA213996 · NCI · WEST VIRGINIA UNIVERSITY · PI AGAZIE, YEHENEW M · 2018 to 2022
$1.7M
SHP2-Mediated Synergy Between EGFR/HER2 and Beta Catenin in Breast OncogenesisR01CA124940 · NCI · WEST VIRGINIA UNIVERSITY · PI AGAZIE, YEHENEW M · 2007 to 2011
$1.2M
NCI NIH HHS R01 CA124940NCI NIH HHS R01 CA213996
6 · The paper itself

Abstract

Previous studies have reported dysregulated cytoplasmic and nuclear expression of the β-catenin protein in triple-negative breast cancer (TNBC) in the absence of

Indexed as

beta CateninCarcinogenesisCell Line, TumorCell ProliferationCell Transformation, NeoplasticFemaleHumansOncogenesProtein Tyrosine Phosphatase, Non-Receptor Type 11Triple Negative Breast Neoplasmsbeta CateninProtein Tyrosine Phosphatase, Non-Receptor Type 11PTPN11 protein, human

Identifiers

PMID34389690
PMCPMC8568672
OpenAlexW3187774619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.