Evidence map›Paper›PMID 34389685›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Albert W Hinman, Hsin-Yi Yeh, Baptiste Roelens, Kei Yamaya, Alexander Woglar, Henri-Marc G Bourbon, Peter Chi, Anne M Villeneuve

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Multifaceted and evolutionarily dynamic interactions betweenbioRxiv : the preprint server for biology · 2026
    Article
  2. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  3. Article
  4. Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Active maintenance of meiosis-specific chromosome structures inbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Albert W HinmanDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Hsin-Yi YehInstitute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Baptiste RoelensDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-0118-0229
Kei YamayaDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Alexander WoglarDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Henri-Marc G BourbonCentre de Biologie Intégrative, Molecular, Cellular & Developmental Biology Unit, Université Fédérale de Toulouse, 31000 Toulouse, France.
Peter ChiInstitute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0001-9229-8729
Anne M VilleneuveDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305; annev@stanford.edu.
Stanford University · USNational Taiwan University · TW

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Meiotic Chromosome Inheritance in C. elegansR35GM126964 · NIGMS · STANFORD UNIVERSITY · PI ANNE M VILLENEUVE · 2018 to 2026
$6.2M
MEIOTIC CHROMOSOME SEGREGATION IN C. ELEGANSR01GM053804 · NIGMS · STANFORD UNIVERSITY · PI VILLENEUVE, ANNE M · 1996 to 2017
$5.7M
NIGMS NIH HHS R01 GM053804NIGMS NIH HHS R35 GM126964NIH HHS P40 OD010440
6 · The paper itself

Abstract

Meiotic recombination plays dual roles in the evolution and stable inheritance of genomes: Recombination promotes genetic diversity by reassorting variants, and it establishes temporary connections between pairs of homologous chromosomes that ensure their future segregation. Meiotic recombination is initiated by generation of double-strand DNA breaks (DSBs) by the conserved topoisomerase-like protein Spo11. Despite strong conservation of Spo11 across eukaryotic kingdoms, auxiliary complexes that interact with Spo11 complexes to promote DSB formation are poorly conserved. Here, we identify DSB-3 as a DSB-promoting protein in the nematode

Indexed as

DNA Breaks, Double-StrandedAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsComputational BiologyGenetic EngineeringGenomeMeiosisOocytesCaenorhabditis elegans ProteinsC. elegansDNA double-strand breaksMei4meiosismeiotic recombination

Identifiers

PMID34389685
PMCPMC8379965
OpenAlexW3188098819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.