ArticleProceedings of the National Academy of Sciences of the United States of America2021
Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Assembly and Stability of Lipid-Coated Silver Nanoparticles: A Combined UV-VIS / Multispectral iSCAT Study.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Light-induced pressurization effect in Au-Ni heterostructures for plasmonic photocatalysis.Nature communications · 2025Article
- Bottom-up Coarse-Grained Models of Asymmetric Membranes.The journal of physical chemistry. B · 2025Article
- Probing the Origins of the Disorder-to-Order Transition of a Modified Cholesterol in Ternary Lipid Bilayers.Journal of the American Chemical Society · 2024Article
- Roadmap on optical sensors.Journal of optics (2010) · 2024Review
- Promises of Plasmonic Antenna-Reactor Systems in Gas-Phase COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Location of the TEMPO moiety of TEMPO-PC in phosphatidylcholine bilayers is membrane phase dependent.Biophysical journal · 2022Article
- Wavelength-Dependent Bifunctional Plasmonic Photocatalysis in Au/Chalcopyrite Hybrid Nanostructures.ACS nano · 2022Article
- Plasmonic photoreactors-coated plastic tubing as combined-active-and-passive antimicrobial flow sterilizer.Journal of materials chemistry. B · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Lipid-coated noble metal nanoparticles (L-NPs) combine the biomimetic surface properties of a self-assembled lipid membrane with the plasmonic properties of a nanoparticle (NP) core. In this work, we investigate derivatives of cholesterol, which can be found in high concentrations in biological membranes, and other terpenoids, as tunable, synthetic platforms to functionalize L-NPs. Side chains of different length and polarity, with a terminal alkyne group as Raman label, are introduced into cholesterol and betulin frameworks. The synthesized tags are shown to coexist in two conformations in the lipid layer of the L-NPs, identified as "head-out" and "head-in" orientations, whose relative ratio is determined by their interactions with the lipid-water hydrogen-bonding network. The orientational dimorphism of the tags introduces orthogonal functionalities into the NP surface for selective targeting and plasmon-enhanced Raman sensing, which is utilized for the identification and Raman imaging of epidermal growth factor receptor-overexpressing cancer cells.
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