Evidence map›Paper›PMID 34389673›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

RyR-mediated Ca

Pedro Lobos, Alex Córdova, Ignacio Vega-Vásquez, Omar A Ramírez, Tatiana Adasme, Jorge Toledo, Mauricio Cerda, Steffen Härtel, Andrea Paula-Lima, Cecilia Hidalgo

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. CRISPR/Cas9-mediatedFrontiers in physiology · 2026
    Article
  3. The CaInternational journal of molecular sciences · 2025
    Review
  4. Synapse-to-Nucleus ERK→CREB Transcriptional Signaling Requires Dendrite-to-Soma CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Amyloid β-Oligomers Inhibit the Nuclear CaAntioxidants (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Real-time imaging ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pedro LobosBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.ORCID 0000-0002-0831-1079
Alex CórdovaBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.ORCID 0000-0002-8001-575X
Ignacio Vega-VásquezBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.ORCID 0000-0002-7613-5919
Omar A RamírezBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.ORCID 0000-0002-9326-2290
Tatiana AdasmeBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.
Jorge ToledoLaboratory for Scientific Image Analysis, Center for Medical Informatics and Telemedicine, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Mauricio CerdaBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.ORCID 0000-0003-3447-1815
Steffen HärtelBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.ORCID 0000-0002-8913-1757
Andrea Paula-LimaBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile; chidalgo@med.uchile.cl acpaulalima@u.uchile.cl.ORCID 0000-0002-0466-7561
Cecilia HidalgoBiomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile; chidalgo@med.uchile.cl acpaulalima@u.uchile.cl.ORCID 0000-0003-1256-9651
University of Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of several hippocampal genes implicated in learning and memory processes requires that Ca

Indexed as

Basic Helix-Loop-Helix ProteinsCalciumCell Culture TechniquesCell NucleusCytoplasmGABA AntagonistsGlutamic AcidHippocampusNeuronsPyridazinesRyanodine Receptor Calcium Release ChannelSynapsesTissue Culture TechniquesBasic Helix-Loop-Helix ProteinsCalciumGABA AntagonistsgabazineGlutamic AcidNpas4 protein, ratPyridazinesRyanodine Receptor Calcium Release ChannelRyR2 protein, ratgabazinegene expressionglutamate uncaginghigh-frequency field stimulationRyR2 channels

Identifiers

PMID34389673
PMCPMC8379958
OpenAlexW3188879132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.