Evidence map›Paper›PMID 34389629›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2021

Transcriptome-wide

Matthew A M Devall, David A Drew, Christopher H Dampier, Sarah J Plummer, Stephen Eaton, Jennifer Bryant, Virginia Díez-Obrero, Jiancheng Mo, Dmitriy Kedrin, Dylan C Zerjav and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Stem Cell Models for Cancer Therapy.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Drug-Resistant Stem Cells: Novel Approach for Colon Cancer Therapy.International journal of molecular sciences · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Matthew A M Devall *Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
David A Drew *Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-8813-0816
Christopher H DampierCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.ORCID 0000-0003-3099-6462
Sarah J PlummerCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Stephen EatonCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Jennifer BryantCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Virginia Díez-ObreroDepartment of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-0163-9872
Jiancheng MoClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Dmitriy KedrinClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-6093-7282
Dylan C ZerjavClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-3248-4340
Oliver Takacsi-NagyClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Lucas T JennelleCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Mourad W AliCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Ömer H YilmazKoch Institute for Integrative Cancer Research, Department of Biology, MIT Cambridge, Massachusetts.ORCID 0000-0002-7577-4612
Victor MorenoDepartment of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-2818-5487
Steven M PowellDigestive Health Center, University of Virginia, Charlottesville, Virginia.
Andrew T ChanClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Center Research Institute, Seattle, Washington.ORCID 0000-0001-5666-9318
Graham CaseyCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia. gc8r@virginia.edu.
Virginia Department of Health · USMassachusetts General Hospital · USUniversitat de Barcelona · ESElliot Hospital · USFred Hutch Cancer Center · USUniversity of Virginia Health System · US

Funding

Using Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CASEY, GRAHAM, GAUDERMAN, WILLIAM JAMES · 2016 to 2020
$9.6M
Inherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4M
Precision Prevention Research ProgramR35CA253185 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew T Chan · 2020 to 2026
$6.9M
Inflammation and Colorectal NeoplasiaR01CA137178 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2009 to 2019
$6.5M
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.R01CA257523 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STAPPENBECK, THADDEUS S · 2021 to 2025
$3.7M
Biology of Colorectal Cancer Risk EnhancersR01CA204279 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM, SCACHERI, PETER CHRISTOPHER · 2016 to 2020
$3.0M
Impact of fasting on intestinal stem cells and cancerR01CA245314 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2020 to 2026
$2.3M
Dietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0M
Impact of Aspirin on the Gut Microbiome and Mucosal MicroenvironmentK01DK120742 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DREW, DAVID A · 2020 to 2024
$793k
Optimizing Gram-positive bacteria as a candidate for targeted anti-tumor therapyF32CA254314 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHUSTER, BENTLEY M. · 2020 to 2022
$151k
NCI NIH HHS F32 CA254314NCI NIH HHS L30 CA209764NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA143237NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA204279NCI NIH HHS R01 CA211184NCI NIH HHS R01 CA245314NCI NIH HHS R01 CA257523NCI NIH HHS R35 CA253185NIDDK NIH HHS K01 DK120742
6 · The paper itself

Abstract

Mechanisms underlying aspirin chemoprevention of colorectal cancer remain unclear. Prior studies have been limited because of the inability of preclinical models to recapitulate human normal colon epithelium or cellular heterogeneity present in mucosal biopsies. To overcome some of these obstacles, we performed

Indexed as

OrganoidsTranscriptomeAspirinColonHumansSequence Analysis, RNAAspirin

Identifiers

PMID34389629
PMCPMC8639779
OpenAlexW3187157749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.