Evidence map›Paper›PMID 34389624›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Differential Regulation of ATP- and UTP-Evoked Prostaglandin E

Timothy S Kountz, Amit Jairaman, Candace D Kountz, Kenneth A Stauderman, Robert P Schleimer, Murali Prakriya

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. CRAC channels as targets for immunotherapy.Current opinion in immunology · 2026
    Review
  3. Article
  4. Pulmonary surfactant and prostaglandin EPhysiological reports · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Timothy S KountzDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Amit JairamanDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-5206-700X
Candace D KountzDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Kenneth A StaudermanCalciMedica, Inc., La Jolla, CA; and.ORCID 0000-0002-8090-4549
Robert P SchleimerDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-8330-0097
Murali PrakriyaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL; m-prakriya@northwestern.edu.ORCID 0000-0003-0781-4480
Northwestern University · USCalciMedica (United States) · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Population-based CRS epidemiology: sex differences, natural history, and long-term outcomes based on clinically-defined phenotypes and biologically-based endotypes - GeisingerP01AI145818 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2019 to 2023
$9.3M
TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
Initiators, biomarkers and mechanisms of epithelial dysfunction and immune pathogenesis in chronic rhinosinusitis and aspirin exacerbated respiratory disease (AERD)R01AI137174 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2018 to 2022
$3.1M
Regulation of airway epithelial cell-mediated inflammation by CRAC channelsR01HL149385 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2019 to 2022
$1.9M
The role of airway epithelial CRAC channels in allergic lung inflammationF31HL151170 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KOUNTZ, TIMOTHY · 2020 to 2022
$86k
NCI NIH HHS P30 CA060553NHLBI NIH HHS F31 HL151170NHLBI NIH HHS R01 HL149385NIAID NIH HHS P01 AI145818NIAID NIH HHS R01 AI137174NIAID NIH HHS T32 AI007476NINDS NIH HHS R01 NS057499
6 · The paper itself

Abstract

The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. Among these, PGE

Indexed as

Adenosine TriphosphateAlarminsCalcium Release Activated Calcium ChannelsCells, CulturedDinoprostoneHumansImmunomodulationInflammationInterleukin-6NFATC Transcription FactorsPhospholipases A2Receptors, Purinergic P2XRespiratory MucosaSignal TransductionUracil NucleotidesAdenosine TriphosphateAlarminsCalcium Release Activated Calcium ChannelsDinoprostoneInterleukin-6NFATC Transcription FactorsPhospholipases A2Receptors, Purinergic P2XUracil Nucleotides

Identifiers

PMID34389624
PMCPMC8816324
OpenAlexW3190273141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.