Evidence map›Paper›PMID 34389568›Full record

ArticleBMJ open2021

Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (ST

Amy S Shah, Michael A Helmrath, Thomas H Inge, Stavra A Xanthakos, Megan M Kelsey, Todd Jenkins, Andrew T Trout, Lorna Browne, Kristen J Nadeau

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04128995 (Surgical or Medical Treatment for Pediatric Type 2 Diabetes), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04128995 phase4active not recruitingnot on this map

Surgical or Medical Treatment for Pediatric Type 2 Diabetes

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2019 to 2026Enrolled88ConditionsDiabetes Mellitus, Type 2, Pediatric Obesity, Bariatric Surgery CandidateArmsAdvanced Medical Therapy and Bariatric Surgery, Advanced Medical Therapy, Bariatric Surgery
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Surgery for the treatment of obesity in children and adolescents.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amy S ShahDivision of Pediatric Endocrinology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA amy.shah@cchmc.org.ORCID 0000-0001-7297-139X
Michael A HelmrathDivision of Pediatric Surgery, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Thomas H IngeDivision of Pediatric Surgery, University of Colorado and Children's Hospital Colorado, Aurora, Colorado, USA.
Stavra A XanthakosDivision of Pediatric Gastroenterology, Hepatology and Nutrition, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Megan M KelseyDivision of Pediatric Endocrinology, University of Colorado, Children's Hospital Colorado, Aurora, Colorado, USA.
Todd JenkinsDivision of Pediatric Surgery, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Andrew T TroutDepartment of Radiology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lorna BrowneDivision of Radiology, University of Colorado, Children's Hospital Colorado, Aurora, Colorado, USA.
Kristen J NadeauDivision of Pediatric Surgery, University of Colorado and Children's Hospital Colorado, Aurora, Colorado, USA.
Cincinnati Children's Hospital Medical Center · USChildren's Hospital Colorado · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PETER J DEMPSEY · 2020 to 2026
$10.8M
Surgical or Medical Treatment for Pediatric Type 2 Diabetes (ST2OMP)R01DK119450 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HELMRATH, MICHAEL A., INGE, THOMAS HARRIS · 2019 to 2023
$3.3M
The Next Generation of Innovative Cardiovascular Clinical/Translational ResearchersK24HL145076 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NADEAU, KRISTEN JANE · 2019 to 2023
$574k
NHLBI NIH HHS K24 HL145076NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK119450
6 · The paper itself

Abstract

introductionThe pathophysiology of type 2 diabetes (T2D) in youth differs from adults and conventional medical treatment approaches with lifestyle change, metformin, thiazolidinediones or insulin are inadequate. Metabolic bariatric surgery (MBS) improves multiple health outcomes in adults with T2D. Initial small, uncontrolled studies of Roux-en-Y gastric bypass have also suggested beneficial effects in adolescents. Definitive studies in youth with T2D are lacking, especially with the now more common form of MBS, vertical sleeve gastrectomy (VSG). The surgical or medical treatment for paediatric type 2 diabetes (ST METHODS AND ANALYSIS: ST ETHICS AND DISSEMINATION: The ST TRIAL REGISTRATION NUMBER: Clinical Trials.Gov NCT04128995.

Indexed as

Diabetes Mellitus, Type 2Gastric BypassObesity, MorbidAdolescentAdultChildHumansProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeYoung Adultlipid disorderspaediatric endocrinologypaediatric surgery

Identifiers

PMID34389568
PMCPMC8365790
OpenAlexW3190084755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.