Evidence map›Paper›PMID 34389553›Full record

ArticleBMJ supportive & palliative care2022

Opioid safety recommendations in adult palliative medicine: a North American Delphi expert consensus.

Jenny Lau, Paolo Mazzotta, Ciara Whelan, Mohamed Abdelaal, Hance Clarke, Andrea D Furlan, Andrew Smith, Amna Husain, Robin Fainsinger, David Hui and 2 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in BMJ supportive & palliative care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Treating cancer-related symptoms in patients exhibiting nonmedical opioid use behaviours: a retrospective chart review study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jenny LauDivision of Palliative care, Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, Ontario, Canada pmazzotta1@gmail.com jenny.lau@uhn.ca.ORCID http://orcid.org/0000-0003-0947-7334
Paolo MazzottaDivision of Palliative Care, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada pmazzotta1@gmail.com jenny.lau@uhn.ca.
Ciara WhelanDivision of Palliative Care, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
Mohamed AbdelaalDivision of Palliative care, Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Hance ClarkeDepartment of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4975-3823
Andrea D FurlanDepartment of Physiatry, Toronto Rehabilitation Institute, Toronto, Ontario, Canada.
Andrew SmithToronto Academic Pain Medicine Institute, Toronto, Ontario, Canada.
Amna HusainDivision of Palliative Care, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
Robin FainsingerDivision of Palliative Care, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
David HuiDepartment of Palliative Care, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nadiya SunderjiDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Camilla ZimmermannDivision of Palliative care, Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4889-0244
University of Toronto · CACentre for Addiction and Mental Health · CAThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDespite the escalating public health emergency related to opioid-related deaths in Canada and the USA, opioids are essential for palliative care (PC) symptom management.Opioid safety is the prevention, identification and management of opioid-related harms. The Delphi technique was used to develop expert consensus recommendations about how to promote opioid safety in adults receiving PC in Canada and the USA.

methodsThrough a Delphi process comprised of two rounds, USA and Canadian panellists in PC, addiction and pain medicine developed expert consensus recommendations. Elected Canadian Society of Palliative Care Physicians (CSPCP) board members then rated how important it is for PC physicians to be aware of each consensus recommendation.They also identified high-priority research areas from the topics that did not achieve consensus in Round 2.

resultsThe panellists (Round 1, n=23; Round 2, n=22) developed a total of 130 recommendations from the two rounds about the following six opioid-safety related domains: (1) General principles; (2) Measures for healthcare institution and PC training and clinical programmes; (3) Patient and caregiver assessments; (4) Prescribing practices; (5) Monitoring; and (6) Patients and caregiver education. Fifty-nine topics did not achieve consensus and were deemed potential areas of research. From these results, CSPCP identified 43 high-priority recommendations and 8 high-priority research areas.

conclusionsUrgent guidance about opioid safety is needed to address the opioid crisis. These consensus recommendations can promote safer opioid use, while recognising the importance of these medications for PC symptom management.

Indexed as

Analgesics, OpioidPalliative MedicineAdultCanadaConsensusDelphi TechniqueHumansAnalgesics, Opioidcancerchronic conditionsclinical decisionseducation and trainingpain

Identifiers

PMID34389553
PMCPMC8862037
OpenAlexW3192061729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.