Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
28 authors at 6 institutions in 5 countries.
Lilan ZhaoDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-9862-1785
Anastasios D GiannouDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-4152-4201
Yang XuDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-2431-4990
Ahmad Mustafa ShiriSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-9472-0038
Imke LieboldSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-9708-4735
Babett SteglichDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Tanja BedkeSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-8246-1684
Tao ZhangSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-9331-8832
Jöran LückeSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Pasquale ScognamiglioDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jan KempskiSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Anna WoestemeierDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-0577-0576
Jing ChenDepartment of Pharmacy, Dong Fang Hospital (900 Hospital of the Joint Logistics Team), School of Medicine, Xiamen University, 350025 Fuzhou, People's Republic of China.ORCID 0000-0003-2434-0010
Theodora AgaliotiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-5898-2751
Dimitra E ZazaraCenter for Obstetrics and Pediatrics, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-5414-1886
Diana LindnerDepartment of Cardiology, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-5477-769X
Melanie JanningDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Jan K HennigsDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.ORCID 0000-0002-7784-8267
Rajesh M JagirdarDepartment of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece.
Ourania S KotsiouDepartment of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece.ORCID 0000-0001-5219-6971
Sotirios G ZarogiannisDepartment of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece.ORCID 0000-0002-3083-3244
Yasushi KobayashiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-0957-9138
Jacob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Sourav GhoshDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-5990-8708
Carla V RothlinDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-5693-5572
Lidia BosurgiSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. n.gagliani@uke.de s.huber@uke.de l.bosurgi@uke.de.ORCID 0000-0002-8775-4950
Samuel HuberSection of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. n.gagliani@uke.de s.huber@uke.de l.bosurgi@uke.de.ORCID 0000-0001-9325-8227
Nicola GaglianiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. n.gagliani@uke.de s.huber@uke.de l.bosurgi@uke.de.ORCID 0000-0001-8514-1395
Universität Hamburg · DEUniversity of Thessaly · GRYale University · US174th hospital of the People's Liberation Army · CNFujian Medical University · CNKarolinska University Hospital · SE
Funding
TAM receptor tyrosine kinases in inflammatory boweldiseaseR01AI089824 · NIAID · YALE UNIVERSITY · PI ROTHLIN, CARLA · 2010 to 2018
$3.9M
NIAID NIH HHS R01 AI089824
6 · The paper itself
Abstract
Malignant pleural effusion (MPE) results from the capacity of several human cancers to metastasize to the pleural cavity. No effective treatments are currently available, reflecting our insufficient understanding of the basic mechanisms leading to MPE progression. Here, we found that efferocytosis through the receptor tyrosine kinases AXL and MERTK led to the production of interleukin-10 (IL-10) by four distinct pleural cavity macrophage (Mφ) subpopulations characterized by different metabolic states and cell chemotaxis properties. In turn, IL-10 acts on dendritic cells (DCs) inducing the production of tissue inhibitor of metalloproteinases 1 (TIMP1). Genetic ablation of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Efferocytosis fuels malignant pleural effusion through TIMP1. · full record | OpenQuestion