ArticleBone2021
Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank.
Article in Bone, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Pooled it
- A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.Arthritis & rheumatology (Hoboken, N.J.) · 2023Pooled it
- The clinical utility of imaging in osteoarthritis and its importance in future prediction of total hip replacement; a nested case-control study within the AGES-Reykjavik cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Opportunistic CT assessment of psoas muscle attenuation and its association with lumbar osteoporosis in total hip arthroplasty candidates.Skeletal radiology · 2026Article
- A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individuals.medRxiv : the preprint server for health sciences · 2026Article
- Outcomes following arthroscopic treatment for femoroacetabular impingement syndrome in patients with ossified labrum.Journal of hip preservation surgery · 2026Article
- Bony landmarks guided mapping of the osteophytes of the elbow osteoarthritis patients: a three dimensional computed tomograph based study.Journal of orthopaedic surgery and research · 2025Article
- Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.Osteoarthritis and cartilage · 2025Article
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- Three-Dimensional Reconstruction of Computed Tomography Imaging Is Not Reliable in Assessing Acetabular Rim Osteophytes or Acetabular Rim Pathology in Patients With Femoroacetabular Impingement.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Influence of acromioclavicular joint arthritis on outcomes after reverse total shoulder.JSES international · 2024Article
- Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis.Frontiers in endocrinology · 2024Review
- Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: Findings from a cross-sectional study in UK Biobank.Osteoarthritis and cartilage · 2023Article
- Big data, big consortia, and pain: UK Biobank, PAINSTORM, and DOLORisk.Pain reports · 2023Article
- Osteoarthritis year in review 2022: imaging.Osteoarthritis and cartilage · 2023Review
- Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis.Nature communications · 2023Article
- Machine Learning-Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank.Rheumatology (Oxford, England) · 2022Article
- Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank.Osteoarthritis and cartilage · 2021Article
- Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach.Wellcome open research · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveIt remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to hip pain. We examined the relationship between rHOA, including its individual components, and hip pain using a novel dual-energy x-ray absorptiometry (DXA)-based method.
methodsHip DXAs were obtained from UK Biobank. A novel automated method obtained minimum joint space width (mJSW) from points placed around the femoral head and acetabulum. Osteophyte areas at the lateral acetabulum, superior and inferior femoral head were derived manually. Semi-quantitative measures of osteophytes and joint space narrowing (JSN) were combined to define rHOA. Logistic regression was used to examine the relationships between these variables and hip pain, obtained via questionnaires.
results6807 hip DXAs were examined. rHOA was present in 353 (5.2%) individuals and was associated with hip pain [OR 2.42 (1.78-3.29)] and hospital diagnosed OA [6.01 (2.98-12.16)]. Total osteophyte area but not mJSW was associated with hip pain in mutually adjusted models [1.31 (1.23-1.39), 0.95 (0.87-1.04) respectively]. On the other hand, JSN as a categorical variable showed weak associations between grade ≥ 1 and grade ≥ 2 JSN with hip pain [1.30 (1.06-1.60), 1.80 (1.34-2.42) respectively]. Acetabular, superior and inferior femoral osteophyte areas were all independently associated with hip pain [1.13 (1.06-1.20), 1.13 (1.05-1.24), 1.10 (1.03-1.17) respectively].
conclusionIn this cohort, the relationship between rHOA and prevalent hip pain was explained by 2-dimensional osteophyte area, but not by the apparent mJSW. Osteophytes at different locations showed important, potentially independent, associations with hip pain, possibly reflecting the contribution of distinct biomechanical pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.