Evidence map›Paper›PMID 34389255›Full record

Observational studyJournal of geriatric oncology2022

Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status.

Christopher E Jensen, Sanah N Vohra, Kirsten A Nyrop, Allison M Deal, Hyman B Muss, Eben I Lichtman, Samuel M Rubinstein, William A Wood, Nicholas J Mangieri, Lee Jamison and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of geriatric oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Cumulative frailty impact on unplanned hospitalization in older patients with cancer and excellent Eastern Cooperative Oncology Group performance.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Observational
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  13. Partnering With All Patients: Ensuring Shared Decision Making and Evidence-Based Management for Underrepresented Groups With Multiple Myeloma.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2023
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Christopher E JensenDivision of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA. Electronic address: christopher.jensen@unchealth.unc.edu.
Sanah N VohraDepartment of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, 2101 McGavran-Greenberg Hall, CB# 7435, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: vohrasn@email.unc.edu.
Kirsten A NyropDivision of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: kirsten_nyrop@med.unc.edu.
Allison M DealLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: allison_deal@med.unc.edu.
Hyman B MussDivision of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: hyman_muss@med.unc.edu.
Eben I LichtmanDivision of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: eben_lichtman@med.unc.edu.
Samuel M RubinsteinDivision of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: samuel_rubinstein@med.unc.edu.
William A WoodDivision of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: william_wood@med.unc.edu.
Nicholas J MangieriLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: nicholas_mangieri@med.unc.edu.
Lee JamisonDivision of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA. Electronic address: lee.jamison@unchealth.unc.edu.
Shakira J GrantDivision of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: shakira_grant@med.unc.edu.
Sascha A TuchmanDivision of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Houpt Building, CB# 7305, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA. Electronic address: sascha_tuchman@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

UNC Oncology K12K12CA120780 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM · 2007 to 2026
$9.6M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
UNC Geriatric Oncology Training Grant (UNC-GO)T32CA233419 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSBY-WHITEHEAD, JAN, MUSS, HYMAN · 2019 to 2023
$729k
NCI NIH HHS K12 CA120780NCI NIH HHS T32 CA057726NCI NIH HHS T32 CA233419
6 · The paper itself

Abstract

objectivesFindings from a brief geriatric assessment (GA) in a cohort of adults with multiple myeloma (MM) are presented, with particular attention to the utility of the GA in identifying important deficits in adults judged to have a normal Karnofsky Performance Status (KPS ≥ 80). MATERIALS AND

methodsAdults age 18 and older with MM were recruited into an observational study from 2018 to 2020. A modified Cancer and Aging Research Group (CARG) GA was administered at enrollment. Enrollees also completed the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life of Cancer Patients Core 30 questionnaire (QLQ-C30), with subscales of physical, social, role, and cognitive functioning (range 0-100; higher values indicate better function). Data were analyzed using descriptive statistics for the full cohort and stratified by concurrent KPS (score < 80 vs ≥ 80).

resultsAmong 89 adults, the mean age was 69.1 years, 68% were aged ≥65 years, and 70% were white. In this cohort, 78% had KPS ≥ 80. Among those with KPS ≥ 80, functional impairments (Timed Up and Go ≥14 s and dependence in ≥1 instrumental activity of daily living) were seen in 30% and 21%, respectively, with 11% reporting ≥1 fall in the prior 6 months. At least two GA-identified deficits were detected in 50% of the overall cohort and in 41% of those with KPS ≥ 80. Among those with KPS ≥ 80, self-reported physical impairment on EORTC QLQ-C30 was noted by 34%.

conclusionUsing a modified CARG GA and EORTC questionnaire, functional impairments were identified among adults considered to have a good performance status based on a KPS (≥ 80). Future studies should focus on using GA measures for therapy assignment and identifying opportunities for intervening upon GA-identified deficits.

Indexed as

Geriatric AssessmentMultiple MyelomaAgedHumansKarnofsky Performance StatusQuality of LifeSurveys and QuestionnairesFunctionGeriatric assessmentMultiple myeloma

Identifiers

PMID34389255
PMCPMC8828804
OpenAlexW3192905741

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.