Evidence map›Paper›PMID 34389002›Full record

ArticleBMC pulmonary medicine2021

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients.

Yan Hu, Si-Ying Ren, Peng Xiao, Feng-Lei Yu, Wen-Liang Liu

Open access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  10. Review
  11. Clinicopathological Analysis of 60 Cases of Pulmonary Cryptococcosis.International journal of general medicine · 2025
    Article
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  13. Article
  14. A Fatal Fungal Infection:Open forum infectious diseases · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yan HuDepartment of Thoracic Surgery, The Second Xiangya Hospital of Central South University, No. 139 Renmin Road, Changsha, 410011, China.
Si-Ying RenDepartment of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Peng XiaoDepartment of Cardiothoracic Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Feng-Lei YuDepartment of Thoracic Surgery, The Second Xiangya Hospital of Central South University, No. 139 Renmin Road, Changsha, 410011, China.
Wen-Liang LiuDepartment of Thoracic Surgery, The Second Xiangya Hospital of Central South University, No. 139 Renmin Road, Changsha, 410011, China. liuwenliang@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe characterized the clinical features, radiographic characteristics, and response to treatment of immunocompetent and immunocompromised patients with pulmonary cryptococcosis (PC).

methodsWe retrospectively reviewed the medical records and radiological profiles of patients diagnosed with PC who received surgical resection between May 2015 and November 2020 in a tertiary referral center.

resultsA total of 21 males and 18 females were included in the study. 23 patients were immunocompetent and 20 out of the 39 were asymptomatic. Immunocompetent patients were diagnosed with PC at a younger age than immunocompromised patients (48.9 vs 57.1 years, P = 0.02). Single nodule pattern was the most frequent lesion pattern (33 out of 39, 84.6%) and right upper lobe was the most common site of location (15 out of 47, 31.9%). The majority of lesions were located peripherally (38 out of 47, 80.9%) and most lesions were 1-2 cm in diameter (30 out of 47, 63.8%). Cavitation was more likely to occur in immunocompromised patients (5 out of 11, 45.5%) than in immunocompetent patients (6 out of 36, 16.7%) (P = 0.04) and there was complete resolution of PC in all patients treated with anti-fungal therapy.

conclusionsImmunocompetent patients were diagnosed with PC at a younger age than immunocompromised patients. Single nodule pattern was the most frequent lesion pattern in PC patients. Cavitation was more likely to occur in immunocompromised patients than in immunocompetent patients.

Indexed as

AdultCryptococcosisFemaleHumansImmunocompetenceImmunocompromised HostLung Diseases, FungalMaleMiddle AgedRadiographyRetrospective StudiesCavitationComputed tomographyFungal infectionImmune statusPulmonary cryptococcosis

Identifiers

PMID34389002
PMCPMC8361630
OpenAlexW3187759318

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.