Evidence map›Paper›PMID 34388579›Full record

ArticleDrug and alcohol dependence2021

Estimating the community prevalence, child traits, and maternal risk factors of fetal alcohol spectrum disorders (FASD) from a random sample of school children.

Philip A May, Julie M Hasken, Stephen R Hooper, Dixie M Hedrick, Julia Jackson-Newsom, Chalise E Mullis, Elizabeth Dobyns, Wendy O Kalberg, David Buckley, Luther K Robinson and 5 more

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Philip A MayNutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, NC, United States; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, NM, United States. Electronic address: Philip_may@unc.edu.
Julie M HaskenNutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, NC, United States.
Stephen R HooperDepartment of Allied Health Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Dixie M HedrickNutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, NC, United States.
Julia Jackson-NewsomOffice of the Vice Chancellor for Research, The University of North Carolina at Greensboro, Greensboro, NC, United States.
Chalise E MullisOffice of the Vice Chancellor for Research, The University of North Carolina at Greensboro, Greensboro, NC, United States.
Elizabeth DobynsOffice of the Vice Chancellor for Research, The University of North Carolina at Greensboro, Greensboro, NC, United States.
Wendy O KalbergCenter on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, NM, United States.
David BuckleyCenter on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, NM, United States.
Luther K RobinsonDepartment of Pediatrics, State University of New York, Buffalo, NY, United States.
Omar Abdul-RahmanDepartment of Genetic Medicine, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, United States.
Margaret P AdamDivision of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA, United States.
Melanie A ManningDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States.
Tamison JewettDepartment of Pediatrics, Wake Forest University, Winston-Salem, NC, United States.
H Eugene HoymeDepartment of Pediatrics, University of Arizona College of Medicine, Tucson, AZ, United States; Sanford Children's Genomic Medicine Consortium, Sanford Health, Sioux Falls, SD, United States.
University of North Carolina at Chapel Hill · USUniversity of North Carolina at Greensboro · USUniversity of New Mexico · USDavid H. Murdock Research Institute · USNebraska Medical Center · USStanford University · USUniversity at Buffalo, State University of New York · USUniversity of Arizona · USUniversity of Washington · USWake Forest University · US

Funding

Prevalence and Traits of FASD in the US Population: Evidence from SchoolsU01AA019894 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2010 to 2017
$9.2M
NIAAA NIH HHS U01 AA019894
6 · The paper itself

Abstract

objectiveUtilize a random sample to estimate the prevalence, child traits, and maternal risk for fetal alcohol spectrum disorders (FASD) in a Southeastern United States county.

methodsFrom all first-grade students (n = 1073) a simple random sample was drawn, and 32 % (n = 231) were consented. All 231 children were examined for dysmorphology and growth, 84 were tested and rated on neurobehavior, and 72 mothers were interviewed for maternal risk.

resultsSignificant differences (α = .05) between the physical traits of children diagnosed with FASD and the entire sample were height, weight, head circumference, body mass index, and total dysmorphology scores, and all three cardinal features of fetal alcohol syndrome: palpebral fissure length, smooth philtrum, and narrow vermilion. Intellectual function and inhibition were not significantly different between FASD and typically-functioning children, but two executive function measures and one visual/spatial measure approached significance (α = .10). Three behavioral measures were significantly worse for the FASD group: parent-rated problems of communication, daily living, and socialization. Significant maternal risk factors reported were postpartum depression, frequency of drinking, and recovery from problem drinking. The prevalence of FASD was 71.4 per 1,000 or 7.1 %. This rate falls clearly within the prevalence range identified in eight larger samples of other communities in the Collaboration on FASD Prevalence (CoFASP) study in four regions of the United States.

conclusionCareful and detailed clinical evaluation of children from small random samples can be useful for estimating the prevalence and traits of FASD in a community.

Indexed as

Fetal Alcohol Spectrum DisordersAlcohol DrinkingChildFemaleHumansMothersPregnancyPrevalenceRisk FactorsSchoolsAlcohol useChildren with FASDFetal alcohol spectrum disordersMaternal risk traits for FASDPrenatal alcohol usePrevalenceWomen

Identifiers

PMID34388579
PMCPMC8499999
OpenAlexW3187256999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.