Evidence map›Paper›PMID 34388578›Full record

ArticleDrug and alcohol dependence2021

Impact of binge drinking during college on resting state functional connectivity.

Tien T Tong, Jatin G Vaidya, John R Kramer, Samuel Kuperman, Douglas R Langbehn, Daniel S O'Leary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tien T TongInterdisciplinary Graduate Program in Neuroscience, The University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1399 Park Ave., 3rd FL, Office 330, New York, NY 10029, USA. Electronic address: tien.tong@mssm.edu.
Jatin G VaidyaDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA. Electronic address: jatin-vaidya@uiowa.edu.
John R KramerDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA. Electronic address: john-kramer@uiowa.edu.
Samuel KupermanDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA. Electronic address: samuel-kuperman@uiowa.edu.
Douglas R LangbehnDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA. Electronic address: douglas-langbehn@uiowa.edu.
Daniel S O'LearyDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA. Electronic address: daniel-oleary@uiowa.edu.

Funding

The Relationship of Adolescent Binge Drinking to Measures of Brain and BehaviorR01AA021165 · NIAAA · UNIVERSITY OF IOWA · PI O LEARY, DANIEL S. · 2013 to 2017
$2.8M
University of Iowa - Research 3T MRI Connectome UpgradeS10OD025025 · OD · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2018 to 2018
$1.9M
NIAAA NIH HHS R01 AA021165NIH HHS S10 OD025025
6 · The paper itself

Abstract

aimThe current study examined the longitudinal effects of standard binge drinking (4+/5+ drinks for females/males in 2 hours) and extreme binge drinking (8+/10+ drinks for females/males in 2 hours) on resting-state functional connectivity.

method119 college students (61 males) were recruited in groups of distinct bingeing patterns at baseline: non-bingeing controls, standard and extreme bingers. Resting-state scans were first obtained when participants were freshmen/sophomores and again approximately two years later. Associations between longitudinal bingeing (reported during this two-year gap) and network connectivity were examined. Network connectivity was calculated by aggregating all edges affiliated with the same network (an edge is a functional connection between two brain regions). The relationship between longitudinal bingeing and connectivity edges was also studied using connectome-based predictive modeling (CPM).

resultsGreater standard bingeing was negatively associated with change in connectivity between Default Mode Network and Ventral Attention Network (DMN-VAN; False Discovery Rate corrected), controlling for initial binge groups, longitudinal network changes, motions, scanner, SES, sex, and age. The correlations between change in DMN-VAN connectivity and change in cognitive performance (Stroop, Digit Span, Letter Fluency, and Trail Making) were also tested, but the results were not significant. Lastly, CPM failed to identify a generalizable predictive model of longitudinal bingeing from change in connectivity edges.

conclusionsBinge drinking is associated with abnormality in networks implicated in attention and self-focused processes, which, in turn, have been implicated in rumination, craving, and relapse. More extensive alterations in functional connectivity might be observed with heavier or longer binge drinking pattern.

Indexed as

Binge DrinkingConnectomeBrainFemaleHumansMagnetic Resonance ImagingMaleNerve NetUniversitiesBinge drinkingConnectome-Based predictive modelingExtreme binge drinkingFunctional connectivityResting-state fMRI

Identifiers

PMID34388578
PMCPMC8464531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.