ArticleSleep medicine2021
Focal limbic sources create the large slow oscillations of the EEG in human deep sleep.
Article in Sleep medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- At-home limbic-targeted transcranial electrical stimulation during sleep: a feasibility study in healthy adults.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment.Nature neuroscience · 2026Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep.Cerebral cortex (New York, N.Y. : 1991) · 2025Review
- Spindle chirp and other sleep oscillatory features in young children with autism.Sleep medicine · 2024Article
- Spindle Chirp and other Sleep Oscillatory Features in Young Children with Autism.bioRxiv : the preprint server for biology · 2023Article
- Neurophysiological mechanisms of implicit and explicit memory in the process of consciousness.Journal of neurophysiology · 2022Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundInitial observations with the human electroencephalogram (EEG) have interpreted slow oscillations (SOs) of the EEG during deep sleep (N3) as reflecting widespread surface-negative traveling waves that originate in frontal regions and propagate across the neocortex. However, mapping SOs with a high-density array shows the simultaneous appearance of posterior positive voltage fields in the EEG at the time of the frontal-negative fields, with the typical inversion point (apparent source) around the temporal lobe.
methodsOvernight 256-channel EEG recordings were gathered from 10 healthy young adults. Individual head conductivity models were created using each participant's own structural MRI. Source localization of SOs during N3 was then performed.
resultsElectrical source localization models confirmed that these large waves were created by focal discharges within the ventral limbic cortex, including medial temporal and caudal orbitofrontal cortex.
conclusionsAlthough the functional neurophysiology of deep sleep involves interactions between limbic and neocortical networks, the large EEG deflections of deep sleep are not created by distributed traveling waves in lateral neocortex but instead by relatively focal limbic discharges.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.