ArticleCurrent biology : CB2021
Deorphanization of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Intracellular regulation of a serotonin-gated ion channel links receptor trafficking to memory.iScience · 2026Article
- Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism.Cell research · 2026Article
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- Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation.PloS one · 2026Article
- Characterisation of an unusual nicotinic acetylcholine receptor subtype preferentially sensitive to biogenic amines.Communications biology · 2025Article
- The dopaminergic system ofRoyal Society open science · 2025Review
- Single-cell transcriptomic profiling ofbioRxiv : the preprint server for biology · 2025Article
- Serotonergic Signaling GovernseNeuro · 2025Article
- Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine-Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nervous system guides behavioral immunity inPeerJ · 2024Review
- The diverse family of Cys-loop receptors inBiophysical reviews · 2023Review
- Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale.Cell · 2023Article
- A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dissecting the Functional Organization of thebioRxiv : the preprint server for biology · 2023Article
- Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The nematode serotonin-gated chloride channel MOD-1: A novel target for anthelmintic therapy.The Journal of biological chemistry · 2022Article
- Forgetting generates a novel state that is reactivatable.Science advances · 2022Article
- C. elegans: out on an evolutionary limb.Immunogenetics · 2022Review
- The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone inmicroPublication biology · 2022Article
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8 authors at 3 institutions in 4 countries.
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Abstract
Pentameric ligand-gated ion channels (LGICs) play conserved, critical roles in both excitatory and inhibitory synaptic transmission and can be activated by diverse neurochemical ligands. We have performed a characterization of orphan channels from the nematode C. elegans, identifying five new monoamine-gated LGICs with diverse functional properties and expression postsynaptic to aminergic neurons. These include polymodal anion channels activated by both dopamine and tyramine, which may mediate inhibitory transmission by both molecules in vivo. Intriguingly, we also find that a novel serotonin-gated cation channel, LGC-50, is essential for aversive olfactory learning of pathogenic bacteria, a process known to depend on serotonergic neurotransmission. Remarkably, the redistribution of LGC-50 to neuronal processes is modulated by olfactory conditioning, and lgc-50 point mutations that cause misregulation of receptor membrane expression interfere with olfactory learning. Thus, the intracellular trafficking and localization of these receptors at synapses may represent a molecular cornerstone of the learning mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.