ArticleCurrent biology : CB2021
Philippine Ayta possess the highest level of Denisovan ancestry in the world.
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Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
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33 citing papers in PubMed.
- Article
- Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Science (New York, N.Y.) · 2026Article
- Homo luzonensis and the role of homoplasy in the morphology of hominin insular species.Cladistics : the international journal of the Willi Hennig Society · 2026Article
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Ancient genomes give insight into 160,000 years of East Asian population dynamics and biological adaptation.Genome biology · 2025Review
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- Revealing the range of equally likely estimates in the admixture model.G3 (Bethesda, Md.) · 2025Article
- Resolving out of Africa event for Papua New Guinean population using neural network.Nature communications · 2025Article
- Article
- Genetic Origins of the Kiritimati Population from Central-Eastern Micronesia.Genome biology and evolution · 2025Article
- Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025Review
- Computational Genomics and Its Applications to Anthropological Questions.American journal of biological anthropology · 2024Review
- A history of multiple Denisovan introgression events in modern humans.Nature genetics · 2024Review
- Article
- Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing.Science advances · 2024Article
- More than a decade of genetic research on the Denisovans.Nature reviews. Genetics · 2024Review
- Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications.Genome biology and evolution · 2023Article
- Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution.Nature reviews. Genetics · 2023Review
- Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals.Molecular biology and evolution · 2023Article
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Authors and funding
47 authors.
Maximilian LarenaHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden. Electronic address: maximilian.larena@ebc.uu.se.
James McKennaHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Federico Sanchez-QuintoHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden; Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.
Carolina BernhardssonHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Carlo EbeoNational Committee on Cultural Education, National Commission for Culture and the Arts, Intramuros, Manila, Philippines; National Museum of the Philippines, Padre Burgos Avenue, Rizal Park, Ermita, Manila, Philippines.
Rebecca ReyesAyta Magbukon Cultural Bearer, Ayta Magbukon Indigenous Cultural Community, Abucay, Bataan, Philippines; National Commission on Indigenous Peoples, Philippines.
Ophelia CaselMindanao Doctors Hospital and Cancer Center, Kabacan, Cotabato, Philippines.
Jin-Yuan HuangMolecular Anthropology and Transfusion Medicine Research Laboratory, Mackay Memorial Hospital, Taipei City 10449, Taiwan.
Kim Pullupul HagadaNational Commission on Indigenous Peoples, Philippines; Young Indigenous Peoples Empowered to Act in Community Engagement, Diffun, Quirino.
Dennis GuilayBalangao Indigenous Cultural Community, Paracelis, Mountain Province, Cordillera Administrative Region, Philippines.
Jennelyn ReyesDepartment of Education - Bataan Division, Bataan, Philippines.
Fatima Pir AllianNisa Ul Haqq fi Bangsamoro, Zamboanga City, Bangsamoro Autonomous Region in Muslim Mindanao, Philippines; Tarbilang Foundation, Inc., Bongao, Tawi-Tawi, Bangsamoro Autonomous Region in Muslim Mindanao, Philippines.
Virgilio MoriTarbilang Foundation, Inc., Bongao, Tawi-Tawi, Bangsamoro Autonomous Region in Muslim Mindanao, Philippines.
Lahaina Sue AzarconCenter for Language and Culture, Quirino State University, Barangay Andres Bonifacio, Diffun, Quirino, Philippines.
Alma ManeraCenter for Language and Culture, Cagayan State University - Andrews Campus, Caritan Highway, Tuguegarao, Cagayan, Philippines.
Celito TerandoTagakaulo Indigenous Cultural Community, Malungon, Sarangani, Philippines; Sulong Tribu Program, Provincial Government of Sarangani, Glan, Sarangani, Philippines.
Lucio JameroAyta Magbukon Cultural Bearer, Ayta Magbukon Indigenous Cultural Community, Abucay, Bataan, Philippines.
Gauden SiregSubanen Indigenous Cultural Community, Lakewood, Zamboanga del Sur, Philippines; Dumendingan Arts Guild Inc., Pagadian City, Zamboanga del Sur, Philippines.
Renefe Manginsay-TremedalDumendingan Arts Guild Inc., Pagadian City, Zamboanga del Sur, Philippines.
Maria Shiela LabosAteneo Institute of Anthropology, Ateneo de Davao University, Roxas Avenue, 8016 Davao City, Philippines; Museo Dabawenyo, Andres Bonifacio Rotunda, Poblacion District, Davao City, Philippines.
Richard Dian VilarCultural Outreach Program, Kaliwat Performing Artists Collective, Gumamela St., Lanang, Davao City, Philippines; Culture, Heritage, and Arts Office, Local Government Unit of Butuan, Butuan City, Philippines.
Acram LatiphInstitute for Peace and Development in Mindanao, Mindanao State University - Marawi Campus, Marawi City, Lanao del Sur, Bangsamoro Autonomous Region in Muslim Mindanao, Philippines.
Rodelio Linsahay SawayTalaandig Indigenous Cultural Community, Lantapan, Bukidnon, Philippines.
Erwin MarteLegal Affairs Office, Indigenous People's Mandatory Representative - Sangguniang Panlalawigan, Bukidnon, Northern Mindanao, Philippines.
Pablito MagbanuaNational Commission on Indigenous Peoples, Philippines; Cuyonon Indigenous Cultural Community, Cuyo Island, Palawan, Philippines.
Amor MoralesSurigaonon Heritage Center, Surigao City, Surigao del Norte, Philippines.
Ismael JavaKabankalan City Cultural and Tourism Foundation, Inc., Kabankalan City, Negros Occidental, Philippines; Cultural Research and Documentation, Negros Museum, Gatuslao St., Bacolod, Negros Occidental, Philippines.
Rudy RevecheCultural Research and Documentation, Negros Museum, Gatuslao St., Bacolod, Negros Occidental, Philippines; Culture and Arts Program, Colegio San Agustin, BS Aquino Drive, Bacolod, Negros Occidental, Philippines.
Becky BarriosPanaghiusa Alang Sa Kaugalingnan Ug Kalingkawasan, Inc., Bunawan, Agusan del Sur, Philippines; Agusan Manobo Indigenous Cultural Community, La Paz, Agusan del Sur, Philippines.
Erlinda BurtonMuseo de Oro, Xavier University - Ateneo de Cagayan, Corrales Avenue, Cagayan de Oro City, Philippines.
Jesus Christopher SalonMuseo de Oro, Xavier University - Ateneo de Cagayan, Corrales Avenue, Cagayan de Oro City, Philippines; City Museum of Cagayan de Oro, Fernandez St., Cagayan de Oro City, Philippines.
Ma Junaliah Tuazon KelsHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Adrian AlbanoKalanguya Indigenous Cultural Community, Tinoc, Ifugao, Cordillera Administrative Region, Philippines; Office of Tinoc Campus Administrator, Ifugao State University, Tinoc, Ifugao, Cordillera Administrative Region, Philippines.
Rose Beatrix Cruz-AngelesHeritage Office, National Commission for Culture and the Arts, Intramuros, Manila, Philippines.
Edison MolanidaHeritage Office, National Commission for Culture and the Arts, Intramuros, Manila, Philippines; Office of the Executive Director, National Commission for Culture and the Arts, Intramuros, Manila, Philippines.
Lena GranehällHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Mário VicenteHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Hanna EdlundHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Jun-Hun LooMolecular Anthropology and Transfusion Medicine Research Laboratory, Mackay Memorial Hospital, Taipei City 10449, Taiwan.
Jean TrejautMolecular Anthropology and Transfusion Medicine Research Laboratory, Mackay Memorial Hospital, Taipei City 10449, Taiwan.
Simon Y W HoSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
Lawrence ReidDepartment of Linguistics, University of Hawai'i at Mānoa, Mānoa, HI, USA; National Museum of the Philippines, Padre Burgos Avenue, Rizal Park, Ermita, Manila, Philippines.
Kurt LambeckResearch School of Earth Sciences, The Australian National University, Canberra, ACT 0200, Australia.
Helena MalmströmHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden; Palaeo-Research Institute, University of Johannesburg, PO Box 524, Auckland Park 2006, South Africa.
Carina SchlebuschHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden; Palaeo-Research Institute, University of Johannesburg, PO Box 524, Auckland Park 2006, South Africa; SciLifeLab, Stockholm and Uppsala, Sweden.
Phillip EndicottDepartment Hommes Natures Societies, Musée de l'Homme, 75016 Paris, Ile de France, France.
Mattias JakobssonHuman Evolution, Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden; Palaeo-Research Institute, University of Johannesburg, PO Box 524, Auckland Park 2006, South Africa; SciLifeLab, Stockholm and Uppsala, Sweden. Electronic address: mattias.jakobsson@ebc.uu.se.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world-∼30%-40% greater than that of Australians and Papuans-consistent with an independent admixture event into Negritos from Denisovans. Together with the recently described Homo luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related. Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time.
Indexed as
HominidaeNeanderthalsAnimalsAsiaAsia, SoutheasternAustraliaHumansPhilippinesRacial Groupsadmixturearchaic introgressionAustralasianDenisovansgenomicsIsland Southeast AsiaNegritoPhilippines
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