ArticleDevelopmental cell2021
An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans.
Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 56 citations in OpenAlex.
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- RG motifs promote piRNA-mediated gene silencing in C. elegans.Nucleic acids research · 2025Article
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- Dynamic control of Argonautes by a rapidly evolving immunological switch.Current biology : CB · 2025Article
- WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis.bioRxiv : the preprint server for biology · 2025Article
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- Recent progress in regulation of aging by non-coding RNAs inAnimal cells and systems · 2025Review
- Piwi mutant germ cells transmit a form of heritable stress that promotes longevity.Aging cell · 2025Article
- Functions and applications of RNA interference and small regulatory RNAs.Acta biochimica et biophysica Sinica · 2024Review
- Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA.Genetics · 2024Article
- Pachytene piRNAs control discrete meiotic events during spermatogenesis and restrict gene expression in space and time.Science advances · 2024Article
- Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA.Nature communications · 2024Article
- Functions of RNAi Pathways in Ribosomal RNA Regulation.Non-coding RNA · 2024Review
- piRNA generation is associated with the pioneer round of translation in stem cells.Nucleic acids research · 2024Article
- Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans.EMBO reports · 2023Article
- Nucleus-independent transgenerational small RNA inheritance inScience advances · 2023Article
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3 authors at 1 institution in 1 country.
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Abstract
Piwi-interacting RNAs (piRNAs) are RNA effectors with key roles in maintaining genome integrity and promoting fertility in metazoans. In Caenorhabditis elegans loss of piRNAs leads to a transgenerational sterility phenotype. The plethora of piRNAs and their ability to silence transcripts with imperfect complementarity have raised several (non-exclusive) models for the underlying drivers of sterility. Here, we report the extranuclear and transferable nature of the sterility driver, its suppression via mutations disrupting the endogenous RNAi and poly-uridylation machinery, and copy-number amplification at the ribosomal DNA locus. In piRNA-deficient animals, several small interfering RNA (siRNA) populations become increasingly overabundant in the generations preceding loss of germline function, including ribosomal siRNAs (risiRNAs). A concomitant increase in uridylated sense rRNA fragments suggests that poly-uridylation may potentiate RNAi-mediated gene silencing of rRNAs. We conclude that loss of the piRNA machinery allows for unchecked amplification of siRNA populations, originating from abundant highly structured RNAs, to deleterious levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.