Evidence map›Paper›PMID 34388333›Full record

ReviewReviews in the neurosciences2022

The effect of SARS-CoV-2 on the nervous system: a review of neurological impacts caused by human coronaviruses.

Colin Day, Carson Studders, Kim Arklie, Asees Kaur, Kyra Teetzen, Rebecca Kirsch, Laila Abelseth, Ian Fraser, Emily Abelseth, Stephanie M Willerth

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews in the neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Colin DayBiomedical Engineering Program, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Carson StuddersDepartment of Mechanical Engineering, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Kim ArklieDepartment of Mechanical Engineering, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Asees KaurDepartment of Mechanical Engineering, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Kyra TeetzenBiomedical Engineering Program, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Rebecca KirschDepartment of Chemistry, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Laila AbelsethCentre for Biomedical Research, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Ian FraserDepartment of Mechanical Engineering, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Emily AbelsethBiomedical Engineering Program, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Stephanie M WillerthDepartment of Mechanical Engineering, University of Victoria, Victoria, BC, Canada V8W 2Y2.ORCID 0000-0002-1665-7723
University of Victoria · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has affected millions of people worldwide. While coronaviruses typically have low rates of neurotropic effects, the massive transmission of SARS-CoV-2 suggests that a substantial population will suffer from potential SARS-CoV-2-related neurological disorders. The rapid and recent emergence of SARS-CoV-2 means little research exists on its potential neurological effects. Here we analyze the effects of similar viruses to provide insight into the potential effects of SARS-CoV-2 on the nervous system and beyond. Seven coronavirus strains (HCoV-OC43, HCoV-HKU1, HCoV-229E, HCoV-NL63, SARS-CoV, MERS-CoV, SARS-CoV-2) can infect humans. Many of these strains cause neurological effects, such as headaches, dizziness, strokes, seizures, and critical illness polyneuropathy/myopathy. Certain studies have also linked coronaviruses with multiple sclerosis and extensive central nervous system injuries. Reviewing these studies provides insight into the anticipated effects for patients with SARS-CoV-2. This review will first describe the effects of other coronaviruses that have caused severe disease (SARS-CoV, MERS-CoV) on the nervous system, as well as their proposed origins, non-neurological effects, and neurological infection mechanisms. It will then discuss what is known about SARS-CoV-2 in these areas with reference to the aforementioned viruses, with the goal of providing a holistic picture of SARS-CoV-2.

Indexed as

Coronavirus OC43, HumanCOVID-19HumansNervous SystemPandemicsSARS-CoV-2central nervous systeminfectionviruses

Identifiers

PMID34388333
PMCPMC8997699
OpenAlexW3192695522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.