Evidence map›Paper›PMID 34388163›Full record

ArticlePloS one2021

Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.

Kristof Molnar, Constantinos Voniatis, Daniella Feher, Gyorgyi Szabo, Rita Varga, Lilla Reiniger, David Juriga, Zoltan Kiss, Eniko Krisch, Gyorgy Weber and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristof MolnarLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Constantinos VoniatisLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Daniella FeherDepartment of Surgical Research and Techniques, Semmelweis University, Budapest, Hungary.
Gyorgyi SzaboDepartment of Surgical Research and Techniques, Semmelweis University, Budapest, Hungary.
Rita VargaLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Lilla Reiniger1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
David JurigaLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Zoltan KissDepartment of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Budapest, Hungary.
Eniko KrischDepartment of Food, Agricultural and Biological Engineering, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Wooster, OH, United States of America.
Gyorgy WeberDepartment of Surgical Research and Techniques, Semmelweis University, Budapest, Hungary.
Andrea FerenczDepartment of Surgical Research and Techniques, Semmelweis University, Budapest, Hungary.
Gabor VargaDepartment of Oral Biology, Semmelweis University, Budapest, Hungary.
Miklos ZrinyiLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Krisztina S NagyLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Angela Jedlovszky-HajduLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-2720-783X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3rd day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.

Indexed as

Membranes, ArtificialAmino AcidsAnimalsBiocompatible MaterialsCell Line, TumorHumansMaleRatsRats, WistarStress, MechanicalAmino AcidsBiocompatible MaterialsMembranes, Artificial

Identifiers

PMID34388163
PMCPMC8362958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.