Evidence map›Paper›PMID 34388113›Full record

ArticleAging2021

Efficacy of graphene oxide-loaded cationic antimicrobial peptide AWRK6 on the neutralization of endotoxin activity and in the treatment of sepsis.

Bo Song, Hongli Zhao, Haiyan Yang, Shengji Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Bo SongDepartment of Emergency, Yantaishan Hospital, Yantai, Shandong Province, China.
Hongli ZhaoDepartment of Senile Diseases, Dongying City Shengli Hospital, Dongying, Shandong Province, China.
Haiyan YangDepartment of Emergency, Yantaishan Hospital, Yantai, Shandong Province, China.
Shengji WangDepartment of Emergency, Linyi People's Hospital, Linyi, Shandong Province, China.
Yantaishan Hospital · CNLinyi People's Hospital · CNShengli Oilfield Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study is to assess the therapeutic effect of graphene oxide (GO) loaded with AWRK6 on endotoxin-induced sepsis.

methodAWRK6/GO was prepared by GO loaded AWRK6, with the structure characterization of AWRK6/GO conducted by atomic force microscope (AFM) and ultraviolet spectrophotometer, the sustained release rate of AWRK6/GO detected by high performance liquid chromatography (HPLC), and the neutralization ability of AWRK6/GO to lipopolysaccharide (LPS) tested by

resultsThe sustained drug release rate of AWRK6/GO reached 85% within 24 hours observed under

conclusionGO loaded with cationic antimicrobial peptide AWRK6 exerts a rosy neutralization effect on endotoxin activity, with no obvious side effects on mice observed, which is of certain application value in the treatment of sepsis.

Indexed as

AnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesEndotoxemiaGraphiteLipopolysaccharidesMacrophagesMiceSepsisSurvival RateTumor Necrosis Factor-alphaAnti-Infective AgentsAntimicrobial Cationic Peptidesgraphene oxideGraphiteLipopolysaccharidesTumor Necrosis Factor-alphaAWRK6AWRK6/GOendotoxingraphenesepticemia

Identifiers

PMID34388113
PMCPMC8386569
OpenAlexW3189732409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.