Evidence map›Paper›PMID 34388021›Full record

ArticleJCO oncology practice2022

Effect of Early Palliative Care on End-of-Life Health Care Costs: A Population-Based, Propensity Score-Matched Cohort Study.

Hsien Seow, Lisa C Barbera, Kimberlyn McGrail, Fred Burge, Dawn M Guthrie, Beverley Lawson, Kelvin K W Chan, Stuart J Peacock, Rinku Sutradhar

Open access · greenAbstract read
In one paragraph

Article in JCO oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Methodologies and characteristics of studies investigating the cost of the palliative phase of cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  2. Pooled it
  3. The impact of early palliative care on the quality of life of patients with advanced pancreatic cancer: The IMPERATIVE case-crossover study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  4. Missed opportunities: delayed in-hospital palliative care consultations in patients with non-metastatic cancers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  5. Review
  6. Association between the timing of palliative care consultation and end-of-life outcomes in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Assessment of a clinical nurse specialist-led early palliative care initiative for patients with advanced pancreatic cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Hsien SeowDepartment of Oncology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-6701-1714
Lisa C BarberaDepartment of Oncology, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-8302-4117
Kimberlyn McGrailDepartment of Family Medicine, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0002-9349-1915
Fred BurgeSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-8130-4644
Dawn M GuthrieDepartment of Health Sciences, Wilfrid Laurier University, Waterloo, ON, Canada.ORCID 0000-0003-3241-6580
Beverley LawsonDepartment of Family Medicine, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-3069-1730
Kelvin K W ChanDepartment of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-2501-3057
Stuart J PeacockSimon Fraser University, Vancouver, BC, Canada.ORCID 0000-0002-8243-8721
Rinku SutradharInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.ORCID 0000-0002-0320-6042
Dalhousie University · CAInstitute for Clinical Evaluative Sciences · CAMcMaster University · CASimon Fraser University · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Toronto · CAWilfrid Laurier University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the impact of early versus not-early palliative care among cancer decedents on end-of-life health care costs.

methodsUsing linked administrative databases, we created a retrospective cohort of cancer decedents between 2004 and 2014 in Ontario, Canada. We identified those who received early palliative care (palliative care service used in the hospital or community 12 to 6 months before death [exposure]). We used propensity score matching to identify a control group of not-early palliative care, hard matched on age, sex, cancer type, and stage at diagnosis. We examined differences in average health system costs (including hospital, emergency department, physician, and home care costs) between groups in the last month of life.

resultsWe identified 144,306 cancer decedents, of which 37% received early palliative care. After matching, we created 36,238 pairs of decedents who received early and not-early (control) palliative care; there were balanced distributions of age, sex, cancer type (24% lung cancer), and stage (25% stage III and IV). Overall, 56.3% of early group versus 66.7% of control group used inpatient care in the last month (

conclusionReceiving early palliative care reduced average health system costs in the last month of life, especially via avoided hospitalizations.

Indexed as

Health Care CostsPalliative CareCohort StudiesDeathHumansOntarioPropensity ScoreRetrospective Studies

Identifiers

PMID34388021
PMCPMC8758090
OpenAlexW3189309799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.