Evidence map›Paper›PMID 34387972›Full record

ArticleBrazilian journal of cardiovascular surgery2021

Expression of MicroRNA-1281, C-Reactive Protein, and Renal Function in Individuals with Abdominal Aortic Aneurysm and their Clinical Correlation after Endovascular Repair.

Lais Missae, Breno Rossoni, Emanuel Junio Ramos Tenorio, Maurício Serra Ribeiro, Daniela Tirapelli, Edwaldo Edner Joviliano

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lais MissaeDivision of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Breno RossoniDivision of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Emanuel Junio Ramos TenorioDivision of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Maurício Serra RibeiroDivision of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Daniela TirapelliDepartment of Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Edwaldo Edner JovilianoDivision of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Clinics Hospital of Ribeirão Preto · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe treatment of infrarenal aortic aneurysms has changed in the last three decades. Endovascular aneurysm repair (EVAR) has become the primary treatment option in anatomically suitable patients with infrarenal aortic aneurysms. However, there is no serum biomarker to be used in EVAR follow-up.

methodsThis is a prospective single-centre study of 30 consecutive patients with abdominal aortic aneurysm (AAA) who underwent EVAR. Serum dosages of micro ribonucleic acid 1281 (miRNA-1281), creatinine, total cholesterol, triglycerides, and C-reactive protein (CRP) were evaluated and angiotomographic evaluations were performed preoperatively and six months after the intervention.

resultsThere was a hyperexpression of miRNA-1281 in patients with AAA and a significant reduction of it after EVAR, from 1.66-fold before EVAR to 0.27 after the procedure (P<0.0001). MiRNA-1281 expression was not influenced by renal function (creatinine: 1.14±0.29, P=0.68), total cholesterol (179.9±59.9, P=0.22), or CRP (1.17±3.5; P=0.48). There is correlation between AAA size and CRP serum levels, however there was no statically significant reduction of CRP after EVAR. DISCUSSION: MiRNA-1281 expression may be influenced by cholesterol, triglycerides levels, and renal function. We found no difference in these markers before and six months after EVAR. However, miRNA-1281 presents a significant reduction in patients with no follow-up complications. We hypothesize that miRNA-1281 expression may be related to aortic wall stress or flow changes.

conclusionMiRNA-1281 may contribute as a possible marker of EVAR follow-up.

Indexed as

Aortic Aneurysm, AbdominalBlood Vessel Prosthesis ImplantationEndovascular ProceduresMicroRNAsC-Reactive ProteinHumansKidneyPostoperative ComplicationsProspective StudiesRetrospective StudiesRisk FactorsTreatment OutcomeC-Reactive ProteinMicroRNAsMIRN1281 microRNA, humanAortic Aneurysm, AbdominalBiomarkersEndovascular Procedures, C-Reactive ProteinMicroRNAs

Identifiers

PMID34387972
PMCPMC8357382
OpenAlexW3183844199

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.