Evidence map›Paper›PMID 34387859›Full record

ArticleEuropean journal of immunology2021

Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay.

William Mouton, Christelle Compagnon, Kahina Saker, Soizic Daniel, Sophia Djebali, Xavier Lacoux, Bruno Pozzetto, Guy Oriol, Daphné Laubreton, Margaux Prieux and 9 more

Abstract readLetter
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Negative immune responses to two-dose mRNA COVID-19 vaccines in renal allograft recipients assessed with simple antibody and interferon gamma release assay cellular monitoring.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

William MoutonJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.ORCID 0000-0002-8455-0952
Christelle CompagnonJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
Kahina SakerJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
Soizic DanielR&D - Immunoassay, bioMérieux S.A., Marcy l'Etoile, France.
Sophia DjebaliCIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
Xavier LacouxR&D - Immunoassay, bioMérieux S.A., Marcy l'Etoile, France.
Bruno PozzettoGIMAP EA 3064 (Groupe Immunité des Muqueuses et Agents Pathogènes), Lyon University, Jean Monnet University, Saint-Etienne, France.
Guy OriolJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
Daphné LaubretonCIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
Margaux PrieuxCIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
Jean-Baptiste FassierLyon University, Ifsttar, UMRESTTE, UMR T_9405, Claude Bernard Lyon 1 University, Lyon, France.
Nicolas GuibertLyon University, Ifsttar, UMRESTTE, UMR T_9405, Claude Bernard Lyon 1 University, Lyon, France.
Amélie Massardier-PilonchéryLyon University, Ifsttar, UMRESTTE, UMR T_9405, Claude Bernard Lyon 1 University, Lyon, France.
Dulce AlfaiateLyon University, Ifsttar, UMRESTTE, UMR T_9405, Claude Bernard Lyon 1 University, Lyon, France.
Franck BerthierR&D - Immunoassay, bioMérieux S.A., Marcy l'Etoile, France.
Thierry WalzerCIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.ORCID 0000-0002-0857-8179
Jacqueline MarvelCIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
Karen Brengel-PesceJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
Sophie Trouiller-AssantJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.

Funding

bioMérieux SAFondation des Hospices Civils de Lyon (HCL)Hospices Civils de Lyonproject IDEXLYON ANR-18-IDEX-0005SFR Biosciences UAR3444/CNRSSFR Biosciences US8/Inserm
6 · The paper itself

Abstract

Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.

Indexed as

AdultAutomation, LaboratoryCells, CulturedCohort StudiesCOVID-19FemaleHumansInterferon-gammaInterferon-gamma Release TestsLymphocyte ActivationMaleMemory T CellsMiddle AgedSARS-CoV-2T-Cell Antigen Receptor SpecificityWhole Body ImagingInterferon-gammaimmune memoryinterferon gamma release assaySARS-CoV-2T-cells response

Identifiers

PMID34387859
PMCPMC8420580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.