Evidence map›Paper›PMID 34387825›Full record

ArticleObesity surgery2021

Effect of Laparoscopic Sleeve Gastrectomy vs. OAGB on Thyroid Function Tests in Patients with Morbid Obesity and Subclinical or Clinical Hypothyroidism.

Khosrow Najjari, Mohammad Talebpour, Hossein Zabihi Mahmoudabadi, Fezzeh Elyasinia, Maryam Abolhasani, Amir Ashrafi, Mehran Sohrabi Maralani, Abdolreza Mehdinavaz, Farhad Kor

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In one paragraph

Article in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Semaglutide therapy and iatrogenic thyrotoxicosis.Endocrinology, diabetes & metabolism case reports · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Laparoscopic Sleeve Gastrectomy: Impact on Body Mass Index and Thyroid Hormones in Euthyroid Obese Patients.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Khosrow NajjariDepartment of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad TalebpourDepartment of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hossein Zabihi MahmoudabadiDepartment of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fezzeh ElyasiniaDepartment of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Maryam AbolhasaniSports Medicine Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Amir AshrafiGolestan Hospital, Jundishapour University of Medical Sciences, Ahvaz, Iran.
Mehran Sohrabi MaralaniDepartment of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abdolreza MehdinavazDepartment of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran.
Farhad KorDepartment of Surgery, Golestan University of Medical Sciences, Gorgan, Iran. Drkor.f@goums.ac.ir.ORCID http://orcid.org/0000-0002-8129-2556
Sina Hospital · IRAhvaz Jundishapur University of Medical Sciences · IRGolestan University · IRTabriz University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs one of the major problems for the health sector, morbid obesity is associated with many hormonal dysfunctions, including thyroid hormone disorders. Few studies have been performed on improving subclinical and clinical hypothyroidism following bariatric surgery. Therefore, we designed and conducted this study to evaluate the effect of various types of bariatric surgery on thyroid hormone levels and to assess the change of levothyroxine requirement in these patients.

methodsThe data of all patients who underwent either sleeve gastrectomy (SG) or one-anastomosis gastric bypass (OAGB) surgery in the 5 years from 2016 to 2020 at our hospital were analyzed retrospectively.

resultsFrom 1486 patients (792 cases of SG and 694 cases of OAGB), 281 patients had preoperative abnormal thyroid function tests: subclinical hypothyroidism (102 patients) and clinical hypothyroidism (179 patients). The T4 level did not change significantly in any of the groups and subgroups. However, the TSH level at the end of the sixth month after SG and OAGB in both groups significantly lowered. Nevertheless, there is no significant difference between the effect of SG and OAGB surgical procedures on the rate of TSH and T4 alterations in both subclinical and clinical hypothyroid patients. In the sixth month after surgery, 49% of clinically hypothyroid patients in the SG group (n = 179) reduced or stopped taking the medication.

conclusionWhereas bariatric surgery reduces TSH levels, it does not significantly alter T4 levels. Furthermore, there is no apparent difference between subclinical and clinical hypothyroidism and different types of bariatric surgery.

Indexed as

Gastric BypassHypothyroidismLaparoscopyObesity, MorbidGastrectomyHumansRetrospective StudiesThyroid Function TestsBariatric surgeryFat-free massFat massHypothyroidismLevothyroxineMorbid obesityOAGBSleeve gastrectomyThyroid function

Identifiers

PMID34387825
OpenAlexW3191899020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.