Evidence map›Paper›PMID 34387719›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Have (R)-[

Fabien Chauveau, Guillaume Becker, Hervé Boutin

Open access · hybridAbstract readScoping Review
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Development and evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Review
  12. Preclinical characterization of [Acta pharmacologica Sinica · 2025
    Article
  13. Review
  14. Article
  15. P2XEJNMMI research · 2024
    Article
  16. Review
  17. TSPO Radioligands for Neuroinflammation: An Overview.Molecules (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 4 countries.

Fabien ChauveauUniversity of Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR5292, INSERM U1028, University Lyon 1, Lyon, France. chauveau@cermep.fr.ORCID http://orcid.org/0000-0002-4177-741X
Guillaume BeckerGIGA - CRC In Vivo Imaging, University Liege, Liege, Belgium.ORCID http://orcid.org/0000-0002-1714-0267
Hervé BoutinFaculty of Biology Medicine and Health, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. herve.boutin@manchester.ac.uk.ORCID http://orcid.org/0000-0002-0029-5246
Université Claude Bernard Lyon 1 · FRManchester Academic Health Science Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe prototypical TSPO radiotracer (R)-[

methodsA systematic MEDLINE (PubMed) search was performed (up to end of year 2020) to extract publications reporting TSPO PET in patients with identified pathologies, excluding studies in healthy subjects and methodological studies.

resultsOf the 288 publications selected, 152 used 13 challengers, and 142 used (R)-[

conclusionsGenerally, challengers confirmed disease-specific initial (R)-[

Indexed as

IsoquinolinesPositron-Emission TomographyBrainHumansRadionuclide ImagingReceptors, GABASignal-To-Noise RatioIsoquinolinesPK 11195Receptors, GABATSPO protein, humanClinical PET imagingNeuroinflammation(R)-[11C]PK11195RadiotracerTranslocator protein 18 kDa (TSPO)

Identifiers

PMID34387719
PMCPMC8712292
OpenAlexW3187399728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.