ArticleCerebral cortex (New York, N.Y. : 1991)2021
Digital Reconstruction of the Neuro-Glia-Vascular Architecture.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Cystatin C and its Role in the Neuro-Glial-Vascular Unit: Implications for Cerebrovascular Diseases and Neurodegeneration.Neuroscience bulletin · 2026Review
- Ultrastructure of astrocytes using volume electron microscopy: A scoping review.The Journal of physiology · 2026Article
- A 3D-1D-0D multiscale model of the neuro-glial-vascular unit for synaptic and vascular dynamics in the dorsal vagal complex.Journal of mathematical biology · 2025Article
- Modeling neuron-astrocyte interactions in neural networks using distributed simulation.PLoS computational biology · 2025Article
- Generating brain-wide connectome using synthetic axonal morphologies.Nature communications · 2025Article
- A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers.PLoS computational biology · 2025Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex.Biomedicines · 2024Article
- Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes.Cells · 2024Review
- Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling.Briefings in bioinformatics · 2024Article
- The Long Journey from Animal Electricity to the Discovery of Ion Channels and the Modelling of the Human Brain.Biomolecules · 2024Review
- Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms.CNS neuroscience & therapeutics · 2024Review
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Review
- Accurate classification of major brain cell types using in vivo imaging and neural network processing.PLoS biology · 2023Article
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- CellRemorph: A Toolkit for Transforming, Selecting, and Slicing 3D Cell Structures on the Road to Morphologically Detailed Astrocyte Simulations.Neuroinformatics · 2023Article
- Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage.American journal of human genetics · 2023Article
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath.Fluids and barriers of the CNS · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interactions in this neuro-glia-vascular ensemble (NGV). The lack of a detailed cytoarchitecture severely restricts the understanding of how they support brain function. To address this problem, we used data from multiple sources to create a data-driven digital reconstruction of the NGV at micrometer anatomical resolution. We reconstructed 0.2 mm3 of the rat somatosensory cortex with 16 000 morphologically detailed neurons, 2500 protoplasmic astrocytes, and its microvasculature. The consistency of the reconstruction with a wide array of experimental measurements allows novel predictions of the NGV organization, allowing the anatomical reconstruction of overlapping astrocytic microdomains and the quantification of endfeet connecting each astrocyte to the vasculature, as well as the extent to which they cover the latter. Structural analysis showed that astrocytes optimize their positions to provide uniform vascular coverage for trophic support and signaling. However, this optimal organization rapidly declines as their density increases. The NGV digital reconstruction is a resource that will enable a better understanding of the anatomical principles and geometric constraints, which govern how astrocytes support brain function.
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