Evidence map›Paper›PMID 34387460›Full record

ArticleBiomacromolecules2021

Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.

Luis A Navarro, Justin J Ryan, Michael Dzuricky, Michael Gradzielski, Ashutosh Chilkoti, Stefan Zauscher

Abstract read
In one paragraph

Article in Biomacromolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Homophily within and across groups.Nature communications · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luis A NavarroDepartment of Mechanical Engineering & Materials Science, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-7536-308X
Justin J RyanDepartment of Mechanical Engineering & Materials Science, Duke University, Durham, North Carolina 27708, United States.
Michael DzurickyDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-1775-2132
Michael GradzielskiInstitut of Chemistry, Technische Universität Berlin, 10623 Berlin, Germany.ORCID 0000-0002-7262-7115
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-1569-2228
Stefan ZauscherDepartment of Mechanical Engineering & Materials Science, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-2290-7178

Funding

ELASTIN FUSION PROTEINSR01GM061232 · NIGMS · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2000 to 2017
$4.6M
Thermally Targeted Drug Delivery by Elastin BiopolymersR01EB000188 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2002 to 2015
$3.9M
Thermally Triggered Multivalent Targeting of TumorsR01EB007205 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2007 to 2015
$2.7M
In situ Enzymatic Synthesis of Aptamer Targeted Polynucleotide Drug Nanoparticles for Cancer TherapyR21EB026590 · NIBIB · DUKE UNIVERSITY · PI ZAUSCHER, STEFAN · 2018 to 2020
$621k
NIBIB NIH HHS R01 EB000188NIBIB NIH HHS R01 EB007205NIBIB NIH HHS R21 EB026590NIGMS NIH HHS R01 GM061232
6 · The paper itself

Abstract

Diblock copolymers are valued for their ability to form thin films with nanoscale features that typically reflect those of their microphase-separated structures in concentrated solution. Here, we show that such self-assembled structures can be easily formed with diblock copolymers composed of thermally responsive polypeptides, such as resilin-like polypeptides (RLP) and elastin-like polypeptides (ELP), by exploiting the inverse temperature transition behavior of ELPs in aqueous media. Specifically, we examine the self-assembly of a series of RLP-

Indexed as

ElastinInsect ProteinsScattering, Small AngleX-Ray DiffractionElastinInsect Proteinsresilin

Identifiers

PMID34387460
PMCPMC9911169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.