Evidence map›Paper›PMID 34387183›Full record

Observational studyInfection control and hospital epidemiology2022

Decreasing incidence of

Andrew T Peters, Chiagozie I Pickens, Michael J Postelnick, Teresa R Zembower, Chao Qi, Richard G Wunderink

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Infection control and hospital epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrew T PetersDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-4241-8849
Chiagozie I PickensDivision of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Michael J PostelnickDepartment of Pharmacy, Northwestern Medicine, Chicago, Illinois.
Teresa R ZembowerDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Chao QiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Richard G WunderinkDivision of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Northwestern University · USNorthwestern Medicine · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2018 to 2026
$24.7M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

objectiveTo describe the epidemiology of

designSingle-center retrospective study with case-control and ecological components.

settingUS private tertiary-care hospital. PARTICIPANTS AND

methodsAll hospitalized patients with AB infection from 2008 to 2019 were identified through laboratory records; for those with AB pneumonia, medical records were queried for detailed characteristics and antibiotic exposures in the 30 days preceding pneumonia diagnosis. Hospital-wide antibiotic consumption data from 2015 through 2019 were obtained through pharmacy records.

resultsIncidence of both pneumonia and nonrespiratory AB infections decreased from 2008 to 2019. Among the 175 patients with AB pneumonia, the most frequent antibiotic exposure was vancomycin (101 patients). During the 2015-2019 period when hospital-wide antibiotic consumption data were available, carbapenem consumption increased, and trends negatively correlated with those of AB pneumonia (

conclusionsWe observed decreasing incidence of AB infection despite concurrently increasing carbapenem consumption, possibly associated with declining vancomycin and quinolone consumption. Future research should evaluate a potential role for glycopeptide and quinolone exposure in the pathogenesis of AB infection.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsPneumonia, BacterialQuinolonesAnti-Bacterial AgentsCarbapenemsHumansIncidenceRetrospective StudiesVancomycinAnti-Bacterial AgentsCarbapenemsQuinolonesVancomycin

Identifiers

PMID34387183
PMCPMC8840999
OpenAlexW3188151259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.